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首页> 外文期刊>Journal of nanoscience and nanotechnology >Clinical Study of the Treatment of Klebsiella pneumoniae with Comprehensive Nursing Intervention Combined with New Nano Silver
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Clinical Study of the Treatment of Klebsiella pneumoniae with Comprehensive Nursing Intervention Combined with New Nano Silver

机译：综合护理干预与新纳米银综合护理干预治疗Klebsiella肺炎的临床研究

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To investigate the inhibitory effect of new nano silver (nAg-NPs) on Klebsiella pneumoniae producing extended spectrum beta-lactamases (EBLs). Clinical interventions are mainly directed to inpatients, or patients with obvious discomfort, symptoms, and signs needing outpatient examination, referral, and clear diagnosis. We randomly selected 88 patients from the rehabilitation department of our hospital from November 2017 to June 2019, and divided them into observation and control groups by drawing lots. Taking ESBL K pneumoniae as the research object, the bactericidal effect of nAg-NPs was determined using the coating method; the minimal inhibitory concentration (MIC) was measured using the broth microdilution method, and the mechanism of action of nAg-NPs on ESBL K. pneumoniae was evaluated by electron microscopy. After the implementation of different nursing management modes, the incidence of risk events in the observation group was significantly lower than that in the control group, and nursing satisfaction was significantly higher than that in the control group. nAg-NPs (>= 0.5 g/mL) had 100% bactericidal effect on ESBL K. pneumoniae, 0.05 g/mL nAg-NPs had obvious bactericidal effect on ESBL K. pneumoniae, 5 g/mL nAg-NPs had obvious bactericidal effect on ESBL K. pneumoniae for 5, 15, 30 and 60 min. Additionally, nAg-NPs showed 3.12 g/mL of MIC. Furthermore, nAg-NPs had a significant effect on the morphology of K. pneumoniae. nAg-NPs shows obvious inhibitory effect on ESBL K. pneumoniae. These results will provide an experimental basis for the further study and clinical application of nAg-NPs with the help of clinical nurses.
机译：为了研究的新的纳米银（NAG-NPS）上肺炎克雷伯菌产超广谱β-内酰胺酶（EBL的）的抑制作用。临床干预措施主要针对住院病人，或患者明显不适，症状和体征需门诊检查，转诊，并明确诊断。我们随机选择88名患者来自我院从十一月到2017年2019年6月的康复科，并通过抽签将他们分为观察组和对照组。服用肺炎ESBL K作为研究对象，使用涂布法测定NAG-NP的杀菌效果;最小抑菌浓度（MIC）是使用微量肉汤稀释法测定，对ESBL肺炎克雷伯菌NAG-NP的作用机制是通过电子显微镜进行评价。不同的护理管理模式实施后，风险事件的观察组发病率显著低于对照组中，护理的满意度明显低于对照组显著高。 NAG纳米粒（> = 0.5克/毫升）对ESBL肺炎克雷伯氏菌100％的杀菌效果，0.05克/毫升NAG纳米粒对ESBL肺炎克雷伯菌明显的杀菌作用，出5μg/ mL NAG纳米粒具有明显的杀菌作用上ESBL肺炎克雷伯氏菌5，15，30和60分钟。此外，NAG纳米粒表明3.12克/ MIC的溶液中。此外，老马纳米粒对肺炎克雷伯菌的形态的显著效果。 NAG纳米粒显示肺炎ESBL K.明显的抑制作用。这些研究结果为进一步研究和NAG-NP的临床护士的帮助临床应用提供实验依据。

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