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首页> 外文期刊>Journal of Molecular Biology >Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion
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Metastasis-promoting anterior gradient 2 protein has a dimeric thioredoxin fold structure and a role in cell adhesion

机译：转移促进前梯度2蛋白质具有二聚体硫氧嘧啶折叠结构和细胞粘附中的作用

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摘要

Anterior gradient 2 (AGR2) is a normal endoplasmic reticulum protein that has two important abnormal functions, amphibian limb regeneration and human cancer metastasis promotion. These normal intracellular and abnormal extracellular roles can be attributed to the multidomain structure of AGR2. The NMR structure shows that AGR2 consists of an unstructured N-terminal region followed by a thioredoxin fold. The protein exists in monomer-dimer equilibrium with a Kd of 8.83 ??M, and intermolecular salt bridges involving E60 and K64 within the folded domain serve to stabilize the dimer. The unstructured region is primarily responsible for the ability of AGR2 to promote cell adhesion, while dimerization is less important for this activity. The structural data of AGR2 show a separation between potential catalytic redox activity and adhesion function within the context of metastasis and development. ?2013 Elsevier Ltd. All rights reserved.
机译：前梯度2（AGR2）是一种正常的内质网蛋白，具有两个重要的异常功能，两栖动物肢体再生和人癌转移促进。 这些正常的细胞内和异常的细胞外角色可归因于AGR2的多群结构。 NMR结构表明，AGR2由非结构化的N末端区域组成，然后是硫氧嘧啶折叠。 蛋白质存在于单体 - 二聚体平衡中，其Kd为8.83Ω·m，并且涉及折叠域内的E60和K64的分子间盐桥用于稳定二聚体。 非结构化区域主要负责Agr2促进细胞粘附的能力，而二聚化对该活性不太重要。 AGR2的结构数据显示在转移和发育的背景下潜在催化氧化还原活性和粘附功能之间的分离。 ？2013年elestvier有限公司保留所有权利。

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  • 来源
    《Journal of Molecular Biology》 |2013年第5期|共15页
  • 作者

    PatelP.; ClarkeC.; BarracloughD.L.; JowittT.A.; RudlandP.S.; BarracloughR.; LianL.-Y.;

  • 作者单位

    Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB United;

    Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB United;

    Institute of Ageing and Chronic Disease University of Liverpool Daulby Street Liverpool L69 3GA;

    Biomolecular Analysis Core Facility Faculty of Life Sciences University of Manchester Dover;

    Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB United;

    Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB United;

    Institute of Integrative Biology University of Liverpool Crown Street Liverpool L69 7ZB United;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 分子生物学;
  • 关键词

    adhesion; AGR2; dimer; NMR; thioredoxin;

    机译：粘附;AGR2;二聚体;NMR;嗜酸剂;

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