• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death
【24h】

Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

机译：燃气素家族成员在炎症信号和细胞死亡中的机制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Gasdermin (GSDM) family consists of Gasdermin A (GSDMA), Gasdermin B (GSDMB), Gasdermin C (GSDMC), Gasdermin D (GSDMD), Gasdermin E (GSDME) and Pejvakin (PJVK). GSDMD is activated by inflammasome-associated inflammatory caspases. Cleavage of GSDMD by human or mouse caspase-1, human caspase-4, human caspase-5, and mouse caspase-11 liberates the N-terminal effector domain from the C-terminal inhibitory domain. The N-terminal domain oligomerizes in the cell membrane and forms a pore of 10-16 nm in diameter, through which substrates of a smaller diameter, such as interleukin-1 beta and interleukin-1 beta, are secreted. The increasing abundance of membrane pores ultimately leads to membrane rupture and pyroptosis, releasing the entire cellular content. Other than GSDMD, the N-terminal domain of all GSDMs, with the exception of PJVK, have the ability to form pores. There is evidence to suggest that GSDMB and GSDME are cleaved by apoptotic caspases. Here, we review the mechanistic functions of GSDM proteins with respect to their expression and signaling profile in the cell, with more focused discussions on inflammasome activation and cell death. (C) 2018 Elsevier Ltd. All rights reserved.
机译：所述Gasdermin（GSDM）家族由Gasdermin A（GSDMA）的，Gasdermin B（GSDMB），Gasdermin C（GSDMC），Gasdermin d（GSDMD），Gasdermin E（GSDME）和Pejvakin（PJVK）。 GSDMD由相关的炎性炎症性血糖激活。通过人或小鼠Caspase-1，人胱天冬酶-4，人Caspase-5和小鼠Caspase-11从C末端抑制结构域释放出N末端效应域的GSDMD切割。 N-末端结构域在细胞膜中低聚，形成直径为10-16nm的孔，通过该孔，通过该孔，较小直径，例如白细胞介素-1β和白细胞介素-1β。膜孔的增加最终导致膜破裂和糊化糊化，释放整个细胞含量。除了GSDMD之外，除了PJVK之外，所有GSDM的N终端域都有能力形成孔隙。有证据表明，GSDMB和GSDME通过凋亡的Caspases裂解。在这里，我们在细胞中审查了GSDM蛋白的机械功能和对细胞中的表达和信号谱，具有更重大讨论炎症和细胞死亡。 （c）2018年elestvier有限公司保留所有权利。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号