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首页> 外文期刊>Journal of Molecular Biology >FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains
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FlyXCDB-A Resource for Drosophila Cell Surface and Secreted Proteins and Their Extracellular Domains

机译：Flyxcdb-果蝇细胞表面和分泌蛋白质和细胞外域的资源

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Genomes of metazoan organisms possess a large number of genes encoding cell surface and secreted (CSS) proteins that carry out crucial functions in cell adhesion and communication, signal transduction, extracellular matrix establishment, nutrient digestion and uptake, immunity, and developmental processes. We developed the FIyXCDB database (http://prodata.swmed.edu/FlyXCDB) that provides a comprehensive resource to investigate extracellular (XC) domains in CSS proteins of Drosophila melanogaster, the most studied insect model organism in various aspects of animal biology. More than 300 Drosophila XC domains were discovered in Drosophila CSS proteins encoded by over 2500 genes through analyses of computational predictions of signal peptide, transmembrane (TM) segment, and GPI-anchor signal sequence, profile-based sequence similarity searches, gene ontology, and literature. These domains were classified into six classes mainly based on their molecular functions, including protein protein interactions (class P), signaling molecules (class S), binding of non protein molecules or groups (class B), enzyme homologs (class E), enzyme regulation and inhibition (class R), and unknown molecular function (class U). Main cellular functions such as cell adhesion, cell signaling, and extracellular matrix composition were described for the most abundant domains in each functional class. We assigned cell membrane topology categories (E, secreted; S, type I/III single-pass TM; T, type II single-pass TM; M, multi-pass TM; and G, GPI-anchored) to the products of genes with XC domains and investigated their regulation by mechanisms such as alternative splicing and stop codon readthrough. (C) 2018 Elsevier Ltd. All rights reserved.
机译：甲氧砜生物的基因组具有编码细胞表面和分泌（CSS）蛋白的大量基因，该蛋白质在细胞粘附和通信中开展关键功能，信号转导，细胞外基质建立，营养消化和摄取，免疫力和发育过程。我们开发了FIYXCDB数据库（http://prodata.swmed.edu/flyxcdb），提供了一种综合资源来调查CSS蛋白质中的细胞外（XC）结构域，在动物生物学的各个方面中学习的昆虫模型生物最多。通过分析信号肽，跨膜（TM）段和GPI-Anchor信号序列，简谱序列相似性搜索，基因本体和基因本体和基因本体和基因本体和基因本体和基因本体和基因序列相似性搜索，所述果蝇在2500多种基因编码的果蝇CSS蛋白中发现了超过2500个基因的果蝇蛋白。文学。这些结构域主要基于其分子函数分为六种类别，包括蛋白质蛋白质相互作用（P），信号分子（S），非蛋白质分子或基团（B类）的结合，酶同源物（e），酶调节和抑制（r）和未知的分子功能（u）。在每个功能阶级中最丰富的结构域描述了诸如细胞粘附，细胞信号传导和细胞外基质组合物的主要细胞功能。我们分配了细胞膜拓扑类别（e，分泌; s，I / III型单通过Tm; t，II型单通过Tm; m，多遍Tm;和g，gpi锚定）到基因的产品通过XC域并通过替代剪接和阻止密码子推高的机制调查其调节。 （c）2018年elestvier有限公司保留所有权利。

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