New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

Tomas Alejandra; Jones Ben; Leech Colin

首页> 外文期刊>Journal of Molecular Biology >New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

【24h】

New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

机译：新的见解进入Beta-Cell GLP-1受体和CAMP信号传导

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Harnessing the translational potential of the GLP-1/GLP-1R system in pancreatic beta cells has led to the development of established GLP-1R-based therapies for the long-term preservation of beta cell function. In this review, we discuss recent advances in the current research on the GLP-1/GLP-1R system in beta cells, including the regulation of signaling by endocytic trafficking as well as the application of concepts such as signal bias, allosteric modulation, dual agonism, polymorphic receptor variants, spatial compartmentalization of cAMP signaling and new downstream signaling targets involved in the control of beta cell function. (C) 2019 Elsevier Ltd. All rights reserved.

机译：利用在胰腺β细胞中GLP-1 / GLP-1R系统的平移潜力导致了已建立的GLP-1R基疗法的发展，用于长期保存β细胞功能。在本综述中，我们讨论了β细胞GLP-1 / GLP-1R系统目前研究的最新进展，包括通过内吞贩的信号传导以及信号偏置，变构调制，双重的概念的应用激动性，多态受体变体，CAMP信号传导的空间划分，以及参与β电池功能控制中的新下游信号靶。（c）2019 Elsevier Ltd.保留所有权利。

著录项

来源
《Journal of Molecular Biology》 |2020年第5期|共20页
作者
Tomas Alejandra; Jones Ben; Leech Colin;
展开▼
作者单位

Imperial Coll London Sect Cell Biol &

Funct Genom Div Diabet Endocrinol &

Metab Dept Med London;

Imperial Coll London Div Diabet Endocrinol &

Metab Sect Invest Med Dept Med London W12 0NN;

SUNY Upstate Med Univ Dept Surg Syracuse NY 13210 USA;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词

相似文献

外文文献
中文文献
专利

1. New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling [J] . Tomas Alejandra, Jones Ben, Leech Colin Journal of Molecular Biology . 2020,第5期

机译：新的见解进入Beta-Cell GLP-1受体和CAMP信号传导
2. Synchronizing Calpha2 + and cAMP oscillations in pancreatic beta-cells: a role for glucose metabolism and GLP-1 receptors? Focus on "Regulation of cAMP dynamics by Ca~(2+) and G protein-coupled receptors in the pancreatic beta-cell: a computational a [J] . George G. Holz, Emma Heart, Colin A. Leech American Journal of Physiology . 2008,第1aPta1期

机译：在胰腺β细胞中同步Calpha2 +和cAMP振荡：葡萄糖代谢和GLP-1受体的作用？着重研究“胰腺β细胞中Ca〜（2+）和G蛋白偶联受体对cAMP动力学的调节：
3. How uniform is cAMP signaling? Focus on "Systems analysis of GLP-1 receptor signaling in pancreatic beta-cells". [J] . Harvey RD American Journal of Physiology . 2011,第4Parta1期

机译：cAMP信号的统一性如何？专注于“胰岛β细胞中GLP-1受体信号转导的系统分析”。
4. Highly Constrained GLP-1 Analogues as Non-Invasive PET Imaging Agents for the Assessment of Pancreatic Beta-Cell Mass [C] . Jung-Mo Ahn, Eunice N. Murage, Su-Tang Lo American Peptide Symposium . 2011

机译：高度约束的GLP-1类似物作为非侵入性PET成像剂，用于评估胰腺β细胞质量
5. Backbone modification of glucagon-like peptide-1 (GLP-1) to alter signaling at the GLP-1 receptor. [D] . Hager, Marlies Veronica. 2017

机译：胰高血糖素样肽1（GLP-1）的骨干修饰，以改变GLP-1受体处的信号传导。
6. Activation of the GLP-1 Receptor Signalling Pathway: A Relevant Strategy to Repair a Deficient Beta-Cell Mass [O] . Bernard Portha, Cécile Tourrel-Cuzin, Jamileh Movassat 2011

机译：GLP-1受体信号通路的激活：修复缺乏的β细胞质量的相关策略。
7. New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling [O] . Alejandra Tomas, Ben Jones, Colin Leech 2020

机译：新的见解进入Beta-Cell GLP-1受体和CAMP信号传导

New Insights into Beta-Cell GLP-1 Receptor and cAMP Signaling

摘要

著录项

相似文献

相关主题

期刊订阅