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Breaking Bad and Breaking Good: beta-Cell Autophagy Pathways in Diabetes

机译:破坏不良和破坏:糖尿病的β-细胞自噬途径

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For many decades the lysosome has been recognized as the terminal center of cellular waste disposal. Products of lysosomal degradation are either recycled in biosynthetic pathways or are further metabolized to produce energy. As such the lysosome was attributed a rather passive role in cellular metabolism merely transforming bulk material into small metabolites. More recently, however, the emerging evidence has brought the lysosome to the center of nutrient sensing as the organelle that harbors a complex signaling machinery which dynamically and actively regulates cell metabolism.
机译:多十年来,溶酶体被认为是蜂窝垃圾处理的终端中心。 溶酶体降解产物在生物合成途径中再循环,或者进一步代谢以产生能量。 因此,溶酶体归因于细胞代谢中的相当被动的作用仅将散装物质转化为小代谢物。 然而,最近,新兴的证据已经将溶酶体带到养分感测的中心,作为哈勃的细胞器,其动态地和积极调节细胞代谢的复杂信号机械。

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