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首页> 外文期刊>Journal of Molecular Biology >Key Concepts and Challenges in Archaeal Transcription
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Key Concepts and Challenges in Archaeal Transcription

机译：古代转录中的主要概念和挑战

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Transcription is enabled by RNA polymerase and general factors that allow its progress through the transcription cycle by facilitating initiation, elongation and termination. The transitions between specific stages of the transcription cycle provide opportunities for the global and gene-specific regulation of gene expression. The exact mechanisms and the extent to which the different steps of transcription are exploited for regulation vary between the domains of life, individual species and transcription units. However, a surprising degree of conservation is apparent. Similar key steps in the transcription cycle can be targeted by homologous or unrelated factors providing insights into the mechanisms of RNAP and the evolution of the transcription machinery. Archaea are bona fide prokaryotes but employ a eukaryote-like transcription system to express the information of bacteria-like genomes. Thus, archaea provide the means not only to study transcription mechanisms of interesting model systems but also to test key concepts of regulation in this arena. In this review, we discuss key principles of archaeal transcription, new questions that still await experimental investigation, and how novel integrative approaches hold great promise to fill this gap in our knowledge. (C) 2019 Elsevier Ltd. All rights reserved.
机译：RNA聚合酶和一般因素使转录能够通过促进引发，伸长和终止来通过转录循环进行。转录周期特定阶段之间的转变为基因表达的全球和基因特异性调节提供了机会。利用不同转录的不同步骤的确切机制和范围在生命域，个体种类和转录单元之间进行调节。然而，令人惊讶的保护程度是显而易见的。转录周期中的类似关键步骤可以通过同源或无关的因素来瞄准，提供进入RNAP机制的洞察和转录机械的演变。 Archaea是Bona Fide原核生物，但使用真核样转录系统，表达细菌样基因组的信息。因此，Archaea不仅提供了研究有趣模型系统的转录机制，而且还提供了在这个舞台中测试规则的关键概念。在这篇综述中，我们讨论了古代转录的关键原则，仍在等待实验调查的新问题，以及新的综合方法如何充分承诺填补我们知识的这种差距。 （c）2019 Elsevier Ltd.保留所有权利。

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