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The Phosphatase PRL-3 Is Involved in Key Steps of Cancer Metastasis

机译：磷酸酶PRL-3涉及癌症转移的关键步骤

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摘要

PRL-3 belongs to the PRL phosphatase family. Its physiological role remains unclear, but many studies have identified that PRL-3 is a marker of cancer progression and shown it to be associated with metastasis. Evidence implicating PRL-3 in various elements of the metastatic process, such as the cell cycle, survival, angiogenesis, adhesion, cytoskeleton remodeling, EMT, motility and invasion, has been reported. Furthermore, several molecules acting as direct or indirect substrates have been identified. However, this information was obtained in many different studies, and it remains difficult to see the larger picture. We therefore systematically collected the published information together and used it to develop a comprehensive signaling network map. By analyzing this network map, we were able to retrieve the signaling pathways via which PRL-3 governs the key steps of the metastatic process in cancer. In this review, we summarize current knowledge of the role of PRL-3 in cancer and the molecular mechanisms involved. We also provide the web- based open-source PRL-3 signaling network map, for use in further studies. (C) 2019 Published by Elsevier Ltd.
机译：PRL-3属于PRL磷酸酶家族。其生理作用仍然尚不清楚，但许多研究发现PRL-3是癌症进展的标志物，并显示它与转移相关。据报道，据报道，暗示PRL-3在转移过程的各种元素中，如细胞周期，存活，血管生成，粘附，细胞骨架重塑，EMT，运动和侵袭。此外，已经鉴定了几种作用作为直接或间接基质的分子。然而，这些信息是在许多不同的研究中获得的，并且仍然很难看到较大的画面。因此，我们系统地将公开的信息集成在一起，并用它用于开发一个全面的信令网络地图。通过分析该网络地图，我们能够检索PRL-3控制癌症中转移过程的关键步骤的信令途径。在本综述中，我们总结了目前对癌症中PRL-3作用的了解和所涉及的分子机制的知识。我们还提供了基于网络的开源PRL-3信令网络地图，用于进一步研究。 （c）2019年由elestvier有限公司发布

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