• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >Viewing Legionella pneumophila Pathogenesis through an Immunological Lens
【24h】

Viewing Legionella pneumophila Pathogenesis through an Immunological Lens

机译：通过免疫透镜查看军团菌肺炎发病机制

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Legionella pneumophila is the causative agent of the severe pneumonia Legionnaires' disease. L. pneumophila is ubiquitously found in freshwater environments, where it replicates within free-living protozoa. Aerosolization of contaminated water supplies allows the bacteria to be inhaled into the human lung, where L. pneumophila can be phagocytosed by alveolar macrophages and replicate intracellularly. The Dot/ lcm type IV secretion system (T4SS) is one of the key virulence factors required for intracellular bacterial replication and subsequent disease. The Dot/lcm apparatus translocates more than 300 effector proteins into the host cell cytosol. These effectors interfere with a variety of cellular processes, thus enabling the bacterium to evade phagosome-lysosome fusion and establish an endoplasmic reticulum-derived Legionella-containing vacuole, which facilitates bacterial replication. In turn, the immune system has evolved numerous strategies to recognize intracellular bacteria such as L. pneumophila, leading to potent inflammatory responses that aid in eliminating infection. This review aims to provide an overview of L. pneumophila pathogenesis in the context of the host immune response. (C) 2019 Published by Elsevier Ltd.
机译：军团菌肺炎是严重肺炎军团氏病的致病因子。 L.浮肿在淡水环境中普遍存在，在淡水环境中，在自由生活原生动物内复制。受污染的水供应的雾化允许细菌吸入人肺中，其中L.肺炎可以通过肺泡巨噬细胞吞噬并细胞内复制。 DOT / LCM IV型分泌系统（T4SS）是细胞内细菌复制和随后疾病所需的关键毒力因子之一。点/ LCM装置将超过300个效应蛋白转化为宿主细胞胞嘧啶。这些效应器干扰了各种细胞过程，从而使细菌能够逃避吞噬物体溶酶体融合并建立内质网衍生的含有军团菌的液体，这有利于细菌复制。反过来，免疫系统已经进化了许多策略来识别细胞内细菌如L.肺炎，导致有助于消除感染的有效炎症反应。本综述旨在在宿主免疫应答的背景下提供L.Pneumophila发病机制的概述。 （c）2019年由elestvier有限公司发布

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号