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Teaching an Old Virus New Tricks: A Review on New Approaches to Study Age-Old Questions in Influenza Biology

机译:教授旧病毒新技巧:研究流感生物学中学古代问题的新方法综述

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Influenza viruses have been studied for over 80 years, yet much about the basic viral lifecycle remain unknown. However, new imaging, biochemical, and sequencing techniques have revealed significant insight into many age-old questions of influenza virus biology. In this review, we will cover the role of imaging techniques to describe unique aspects of influenza virus assembly, biochemical techniques to study viral genomic organization, and next-generation sequencing to explore influenza genomic evolution. Our goal is to provide a brief overview of how emerging techniques are being used to answer basic questions about influenza viruses. This is not a comprehensive list of emerging techniques, rather ones that we feel will continue to make significant contributions to field of influenza biology. (C) 2019 Elsevier Ltd. All rights reserved.
机译:已经研究过80年多的流感病毒,但基本的病毒生命周期仍然未知。 然而,新的成像,生物化学和测序技术揭示了对流感病毒生物学的许多古老问题的重要见解。 在本综述中,我们将涵盖成像技术来描述流感病毒组件的独特方面,生化技术来研究病毒基因组组织的生物化学技术,以及下一代测序探索流感基因组进化。 我们的目标是简要概述新兴技术如何用于回答有关流感病毒的基本问题。 这不是新兴技术的全面列表,而是我们认为将继续对流感生物学领域进行重大贡献。 (c)2019 Elsevier Ltd.保留所有权利。

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