Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells

Karl Martin; Sommer Christian; Gabriel Christian H.; Hecklau Katharina; Venzke Melanie; Hennig Anna Floriane; Radbruch Andreas; Selbach Matthias; Baumgrass Ria

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Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells

机译：组蛋白甲基转移酶EHMT1至FoxP3 TSDR的募集抵消了诱导的调节性T细胞的分化

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Differentiation toward CD4(+) regulatory T (Treg) cells is essentially dependent on an epigenetic program at Treg signature genes, which involves remodeling of the Treg-specific demethylated regions (TSDRs). In particular, the epigenetic status of the conserved non-coding sequence 2 of Foxp3 (Foxp3 TSDR) determines expression stability of the master transcription factor and thus Treg lineage identity. However, the molecular mechanisms controlling the epigenetic remodeling at TSDRs in Treg and conventional T cells are largely unknown.

机译：对CD4（+）调节性T（Treg）细胞的分化基本上依赖于Treg标志性基因的表观遗传程序，其涉及重新于特异性去甲基化区域（TSDR）的重塑。特别地，Foxp3（FoxP3 TSDR）的保守非编码序列2的表观遗传状态决定了母转录因子的表达稳定性，从而确定了Treg谱系身份。然而，在Treg和常规T细胞中控制TSDRS的表观遗传重塑的分子机制在很大程度上是未知的。

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来源
《Journal of Molecular Biology》 |2019年第19期|共20页
作者
Karl Martin; Sommer Christian; Gabriel Christian H.; Hecklau Katharina; Venzke Melanie; Hennig Anna Floriane; Radbruch Andreas; Selbach Matthias; Baumgrass Ria;
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作者单位

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

Helmholtz Assoc Max Delbruck Ctr Mol Med Proteome Dynam Robert Rossle Str 10 D-13125 Berlin;

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

German Rheumatism Res Ctr DRFZ Cell Biol Charitepl 1 D-10117 Berlin Germany;

Helmholtz Assoc Max Delbruck Ctr Mol Med Proteome Dynam Robert Rossle Str 10 D-13125 Berlin;

German Rheumatism Res Ctr DRFZ Signal Transduct Charitepl 1 D-10117 Berlin Germany;

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原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
epigenetics; vitamin C; T helper cell; DNA-pull down; mass spectrometry; ascorbate;

机译：表观遗传学;维生素C;T辅助细胞;DNA拉下;质谱;抗坏血酸;

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专利

1. Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells [J] . Karl Martin, Sommer Christian, Gabriel Christian H., Journal of Molecular Biology . 2019,第19期

机译：组蛋白甲基转移酶EHMT1至FoxP3 TSDR的募集抵消了诱导的调节性T细胞的分化
2. DNA Methyltransferase 3b Regulates Nerve Growth Factor-Induced Differentiation of PC12 Cells by Recruiting Histone Deacetylase 2 [J] . Shoumei Bai, Kalpana Ghoshal, Jharna Datta, Molecular and Cellular Biology . 2005,第2期

机译：DNA甲基转移酶3b调节组蛋白脱乙酰基酶2调节神经生长因子诱导的PC12细胞分化。
3. Inhibition of Histone Methyltransferases EHMT1/2 Reverses Amyloid- beta-Induced Loss of AMPAR Currents in Human Stem Cell-Derived Cortical Neurons [J] . Lin Lin, Liu Aiyi, Li Hanqin, Journal of Alzheimer's disease: JAD . 2019,第4期

机译：抑制组蛋白甲基转移酶EHMT1 / 2反转淀粉样蛋白β诱导的人干细胞衍生的皮质神经元中的氨分布丧失
4. Role of Histone Acetyltransferase and Deacetylase in the Retinoic Acid-Induced Differentiation of F9 Cells [C] . Chunyuan Jin, Hongie Li, Masami Horikoshi, Symposium on food factors in health promotion and disease prevention . 2003

机译：组蛋白乙酰转移酶和脱乙酰化酶在视黄酸诱导的F9细胞分化中的作用
5. Small-molecule Modulators of Pancreatic Ductal Cells: Histone Methyltransferases and β-Cell Transdifferentiation [D] . Yuan, Yuan 2012

机译：胰导管细胞的小分子调节剂：组蛋白甲基转移酶和β细胞转分化
6. T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) Signaling Converge on DNA (Cytosine-5)-methyltransferase to Control forkhead box protein 3 (foxp3) Locus Methylation and Inducible Regulatory T Cell Differentiation [O] . Chaoran Li, Peter J. R. Ebert, Qi-Jing Li 2013

机译：T细胞受体（TCR）和转化生长因子β（TGF-β）信号在DNA（Cytosine-5）-甲基转移酶上汇聚以控制叉头盒蛋白3（foxp3）基因座甲基化和诱导性调节性T细胞分化
7. DNA Methyltransferase 3b Regulates Nerve Growth Factor-Induced Differentiation of PC12 Cells by Recruiting Histone Deacetylase 2 [O] . Bai, Shoumei, Ghoshal, Kalpana, Datta, Jharna, 2005

机译：DNA甲基转移酶3b调节组蛋白脱乙酰基酶2调节神经生长因子诱导的PC12细胞分化。

Recruitment of Histone Methyltransferase Ehmt1 to Foxp3 TSDR Counteracts Differentiation of Induced Regulatory T Cells

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