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首页> 外文期刊>Journal of Molecular Biology >Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis
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Polycomb Group Gene E(z) Is Required for Spermatogonial Dedifferentiation in Drosophila Adult Testis

机译：PolycomB组Gene E（Z）是果蝇在果蝇成年睾丸中的精牙科去生

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摘要

Dedifferentiation is an important process to replenish lost stem cells during aging or regeneration after injury to maintain tissue homeostasis. Here, we report that Enhancer of Zeste [E(z)], a component of the Polycomb repression complex 2 (PRC2), is required to maintain a stable pool of germline stem cells (GSCs) within the niche microenvironment. During aging, germ cells with reduced E(z) activity cannot meet that requirement, but the defect arises from neither increased GSC death nor premature differentiation. Instead, we found evidence that the decrease of GSCs upon the inactivation of E(z) in the germline could be attributed to defective dedifferentiation. During recovery from genetically manipulated GSC depletion, E(z) knockdown germ cells also fail to replenish lost GSCs. Taken together, our data suggest that E(z) acts intrinsically in germ cells to activate dedifferentiation and thus replenish lost GSCs during both aging and tissue regeneration. (C) 2017 Elsevier Ltd. All rights reserved.
机译：Deffifferentiation是在损伤后造成衰老或再生后的损失干细胞以维持组织稳态的重要过程。这里，我们报告了Zeste的增强剂[E（Z）]，Polycomb抑制复合物2（PRC2）的组分，需要在Niche微环境中保持稳定的种系干细胞（GSC）。在衰老期间，具有降低的E（Z）活性的生殖细胞不能满足该要求，但缺陷既不增加GSC死亡也不会过早分化。相反，我们发现证据表明，在种系中E（Z）的灭活后GSC的降低可能归因于缺陷的去细化性。在从遗传操纵的GSC耗尽中恢复期间，E（Z）敲低胚芽细胞也未能补充丢失的GSC。我们的数据表明，E（Z）在生殖细胞中致力于激活去除湿，从而在老化和组织再生期间补充损失的GSC。 （c）2017 Elsevier Ltd.保留所有权利。

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  • 来源
    《Journal of Molecular Biology》 |2017年第13期|共12页
  • 作者

    Eun Suk Ho; Feng Lijuan; Cedeno-Rosario Luis; Gan Qiang; Wei Gang; Cui Kairong; Zhao Keji; Chen Xin;

  • 作者单位

    Johns Hopkins Univ Dept Biol Mudd 307B 3400 North Charles St Baltimore MD 21218 USA;

    Johns Hopkins Univ Dept Biol Mudd 307B 3400 North Charles St Baltimore MD 21218 USA;

    Johns Hopkins Univ Dept Biol Mudd 307B 3400 North Charles St Baltimore MD 21218 USA;

    Johns Hopkins Univ Dept Biol Mudd 307B 3400 North Charles St Baltimore MD 21218 USA;

    NHLBI Lab Mol Immunol NIH Bethesda MD 20892 USA;

    NHLBI Lab Mol Immunol NIH Bethesda MD 20892 USA;

    NHLBI Lab Mol Immunol NIH Bethesda MD 20892 USA;

    Johns Hopkins Univ Dept Biol Mudd 307B 3400 North Charles St Baltimore MD 21218 USA;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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