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首页> 外文期刊>Journal of Molecular Biology >Life and Death of Yeast Telomerase RNA
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Life and Death of Yeast Telomerase RNA

机译：酵母端粒酶RNA的生死

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Abstract Telomerase reverse transcriptase elongates telomeres to overcome their natural attrition and allow unlimited cellular proliferation, a characteristic shared by stem cells and the majority of malignant cancerous cells. The telomerase holoenzyme comprises a core RNA molecule, a catalytic protein subunit, and other accessory proteins. Malfunction of certain telomerase components can cause serious genetic disorders including dyskeratosis congenita and aplastic anaemia. A hierarchy of tightly regulated steps constitutes the process of telomerase biogenesis, which, if interrupted or misregulated, can impede the production of a functional enzyme and severely affect telomere maintenance. Here, we take a closer look at the budding yeast telomerase RNA component, TLC1, in its long lifetime journey around the cell. We review the extensive knowledge on TLC1 transcription and processing. We focus on exciting recent studies on telomerase assembly, trafficking, and nuclear dynamics, which for the first time unveil striking similarities between the yeast and human telomerase ribonucleoproteins. Finally, we identify questions yet to be answered and new directions to be followed, which, in the future, might improve our knowledge of telomerase biology and trigger the development of new therapies against cancer and other telomerase-related diseases. Graphical Abstract Display Omitted Highlights ? Yeast telomerase is composed of a single RNA bound by Est1-3 and Pop1, 6, and 7 proteins. ? The ribonucleoprotein diffuses freely in the nucleus, forming rare stable interactions with telomeres. ? Yeast telomeric repeat-containing RNA clusters telomerase molecules and directs them to short telomeres. ? Cajal bodies are not essential for telomerase function or its delivery to telomeres.
机译：摘要端粒酶逆转录酶伸长粒子克服自然磨损，允许无限制的细胞增殖，由干细胞和大多数恶性癌细胞共享的特征。端粒酶全酶包含核心RNA分子，催化蛋白质亚基和其他辅助蛋白。某些端粒酶组分的故障可能导致严重的遗传疾病，包括障碍症症，包括伴有疑似同胞和血栓性贫血。紧压步骤的层次构成端粒酶生物发生的过程，如果中断或被误导，可以妨碍官能酶的产生并严重影响端粒维护。在这里，我们仔细看看萌芽的酵母端粒酶RNA组分TLC1，在其周围的细胞周围的寿命长。我们审查了关于TLC1转录和加工的广泛知识。我们专注于令人兴奋的最近对端粒酶组装，贩运和核动力学的研究，这是第一次揭开酵母和人端粒酶核糖核糖蛋白之间的引人注目的相似性。最后，我们确定了尚未回答的问题，并在将来可能改善我们对端粒酶生物学的知识并引发对癌症和其他相关疾病的新疗法的发展。图形抽象显示省略了亮点？酵母端粒酶由由EST1-3和POP1,6和7个蛋白质结合的单个RNA组成。还是核糖核蛋白在细胞核中自由扩散，形成与端粒的罕见稳定的相互作用。还是酵母直粒体重复的RNA簇端粒酶分子并将它们引导至细胞内。还是CAJAL身体对端粒酶功能不是必需的，或者其交付给端粒。

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