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首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Multi-modal imageability and degradation characteristics of high-borate glass systems for transient embolization
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Multi-modal imageability and degradation characteristics of high-borate glass systems for transient embolization

机译：瞬态栓塞高硼酸玻璃系统的多模态意象与降解特性

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Two glass series were developed based on the substitution of a monovalent glass modifier for a di- or trivalent ion in a high borate glass system. The BRS series consists of compositions 0.70 B2O3 -0.30-X Rb2O - X SrO, and the BRG series consists of compositions 0.70 B2O3-0.30-X Rb2O-X Ga2O3, where 0.00 <= X <= 0.10 in increments of 0.2. All glasses were characterized in order to examine their composition-structure-property relationships, and to assess their potential for use as degradable, radiopaque embolic agents. Glasses were melt quenched, and evaluated in terms of structural changes (B-11 MAS-NMR, density, and glass transition temperature), changes in radiopacity (both CT and MRI), and changes in degradation timeframes under simulated physiological conditions. Structural analysis determined there was no change in the B4% of the BRS series, despite a linear increase in density and Tg. The strontium acts as a crosslinker, creating a more hydrolytically stable network, which leads to longer dissolution times. Conversely, the BRG series displayed a linear decrease in the B4%, a decrease in density (Tg data not available), yet a slight increase in hydrolytic stability is also observed. Gallium most likely acts more as a glass former than a glass modifier, thereby sequestering oxygens from the tetrahedral boron centers, creating trigonal B3 centers and tetrahedral gallium. All glasses were found to be imageable on CT (intensity > 3200 HU at 120 kVp), and invisible on clinical MR imaging modalities.
机译：基于在高硼酸盐玻璃系统中的二价玻璃改性剂的取代来开发两个玻璃系列。 BRS系列由组合物0.70b2O3 -0.30-x RB2O-x SRO组成，BRG系列由组合物0.70b203-0.30-x RB2O-X Ga2O3组成，其中0.00 <= x <= 0.10，增量为0.2。所有眼镜的特征是为了检查它们的组成结构性质关系，并评估其用作可降解的无线电栓塞剂的可能性。玻璃熔体淬火，并根据结构变化（B-11MAS-NMR，密度和玻璃化转变温度），在模拟生理条件下的降解时间帧的变化和变化的辐射缺失性（CT和MRI）的变化。结构分析确定BRS系列的B4％没有变化，尽管密度和Tg线性增加。锶用作交联剂，产生更水解的稳定网络，这导致更长的溶解时间。相反，BRG系列在B4％中显示线性降低，密度降低（不可用的TG数据），但也观察到水解稳定性的轻微增加。镓最有可能作为比玻璃改性剂更高的玻璃前剂，从而螯合来自四面体硼中心的氧气，产生Trigonal B3中心和四面体镓。发现所有眼镜都在CT（强度> 3200uHu在120 kVP）上是可想象的，并且在临床MR成像方式上看不见。

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