...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Non-Crystalline Solids: A Journal Devoted to Oxide, Halide, Chalcogenide and Metallic Glasses, Amorphous Semiconductors, Non-Crystalline Films, Glass-Ceramics and Glassy Composites >Novel bioactive glass cross-linked PVA hydrogel with enhanced chondrogenesis properties and application in mice chondrocytes for cartilage repair
【24h】

Novel bioactive glass cross-linked PVA hydrogel with enhanced chondrogenesis properties and application in mice chondrocytes for cartilage repair

机译：新型生物活性玻璃交联PVA水凝胶，具有增强的软骨发生性能及其在小鼠软骨细胞中的应用软骨修复

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The synthetic hydrogel owns huge potential and broad prospects in cartilage tissue engineering due to a series of unique properties, such as bioactivity, the nutrition ions release ability, high mechanical properties and chondrogenesis capacity. Bioactive glass (BG) and PVA have been widely investigated and reported with safety and excellent biocompatibility as tissue engineering materials. In this study, we have synthesized a novel composite hydrogel formed by crosslinking between bioactive glass and PVA for cartilage repair, furthermore, we have explored the reaction mechanism of this hydrogel. It was found that hydrogen bonding was formed by the hydroxyl groups in PVA combining with the oxygen atoms from the non-bridge Si-O bond in bioactive glass, which can explain better mechanical properties for PM group than that of PVA. The tensile and compressive stress of PM5 hydrogel group has reached 4.8 MPa and 1.8 MPa equaling mechanical properties of natural articular cartilage. Moreover, the hydrogel can significantly support the proliferation of mice chondrocytes in vitro. Meanwhile, it can also effectively upregulate the expression of chondrogenesis related genes (AGGRECAN, SOX9, COL2). Therefore, the novel hydrogel possesses excellent properties in cartilage repair, and exhibits potential medical applications in the future.
机译：由于一系列独特的性质，例如生物活性，营养离子释放能力，高机械性能和软骨发生能力，合成水凝胶在软骨组织工程中拥有巨大的潜力和广阔前景。生物活性玻璃（BG）和PVA已被广泛研究，并以安全性和优异的生物相容性作为组织工程材料，报道。在这项研究中，我们合成了一种通过对软骨修复的生物活性玻璃和PVA之间的交联形成的新型复合水凝胶，此外，我们探讨了该水凝胶的反应机理。发现通过PVA中的羟基与来自生物活性玻璃中的非桥Si-O键合的PVA中的羟基形成氢键，这可以解释PM组的更好的机械性能而不是PVA。 PM5水凝胶基的拉伸和抗压应力达到4.8MPa和1.8MPa等于自然关节软骨的机械性能。此外，水凝胶可以显着支持体外小鼠软骨细胞的增殖。同时，它还可以有效地上调软骨发生相关基因的表达（eggrecan，Sox9，Col2）。因此，新型水凝胶在软骨修复中具有优异的性能，并在未来展示潜在的医疗应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号