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首页> 外文期刊>Biosciences Biotechnology Research Asia >Screening of Glypican- 3 Expression in Human Normal versus Benign and Malignant Tissues: A Comparative Study Glypican- 3 expression in cancers
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Screening of Glypican- 3 Expression in Human Normal versus Benign and Malignant Tissues: A Comparative Study Glypican- 3 expression in cancers

机译：人正常组织与良性和恶性组织中Glypican-3表达的筛选：癌症中Glypican-3表达的比较研究

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摘要

Glypican-3 is a heparan sulfate proteoglycans (HSPGs) expressed at plasma membrane surface. Several studies demonstrated the re-expression of glypican-3 during the malignant transformation. Glypican-3 expression in hepatocellular carcinoma was suggested to be a diagnostic marker for differential diagnosis of hepatic nodules. The aim of the study is to evaluate the diagnostic value of glypican-3 as tumor marker not only in liver tumors but also in tumors of the other organs. A total of 95 surgically excised human tissues were subjected to immunohistochemical staining using a monoclonal antibody specific for glypican-3. These human tissues cover most of the common normal, benign, malignant and metastatic tumors originated from 27 anatomic sites. The immunohistochemical results revealed that glypican-3 was expressed in 17.4% of the normal tissues studied including stomach, small intestine, kidney (Normal cortex), and pancreas, while, the expression for glypican-3 was positive in 41.8 % of the benign and malignant tumors. The most frequent expressing tumor was hepatocellular carcinoma. Moreover, for the first time, several tumor entities showed glypican-3 expression including malignant meningioma, Hodgkin's lymphoma, B-non Hodgkin's lymphoma,T-non Hodgkin's lymphoma.
机译：Glypican-3是在质膜表面表达的硫酸乙酰肝素蛋白聚糖（HSPG）。几项研究证明了glypican-3在恶性转化过程中的重新表达。 Glypican-3在肝细胞癌中的表达被认为是肝结节鉴别诊断的诊断标志。该研究的目的是评估glypican-3作为肿瘤标志物的诊断价值，不仅在肝肿瘤中，而且还在其他器官的肿瘤中。使用对glypican-3特异的单克隆抗体，对总共95个手术切除的人体组织进行了免疫组织化学染色。这些人体组织覆盖了源自27个解剖部位的大多数常见的正常，良性，恶性和转移性肿瘤。免疫组化结果显示，在研究的正常组织中，胃，小肠，肾脏（正常皮质）和胰腺中有17.4％的人表达了glypican-3，而在良性和正常人中，glypican-3的表达为阳性。恶性肿瘤。表达最频繁的肿瘤是肝细胞癌。此外，首次有几个肿瘤实体显示出glypican-3表达，包括恶性脑膜瘤，霍奇金淋巴瘤，B-非霍奇金淋巴瘤，T-非霍奇金淋巴瘤。

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