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首页> 外文期刊>Journal of Neurophysiology >Discharge patterns in the lateral superior olive of decerebrate cats
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Discharge patterns in the lateral superior olive of decerebrate cats

机译：放电模式在Deferebrate Cats的横向高级橄榄中

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Anatomical and pharmacological studies have shown that the lateral superior olive (LSO) receives inputs from a number of sources and that LSO cells can alter the balance of their own excitatory and inhibitory drive. It is thus likely that the ongoing sound-evoked responses of LSO cells reflect a complex interplay of excitatory and inhibitory events, which may be affected by anesthesia. The goal of this study was to characterize the temporal discharge patterns of single units in the LSO of unanesthetized, decerebrate cats in response to long-duration ipsilat-eral best-frequency tone bursts. A decision tree is presented to partition LSO units on the basis of poststimulus time histogram shape, adaptation of instantaneous firing rate as a function of time, and sustained discharge rate. The results suggest that LSO discharge patterns form a continuum with four archetypes: sustained choppers that show two or more peaks of activity at stimulus onset and little adaptation of rate throughout the response, transient choppers that undergo a decrease in rate that eventually stabilizes with time, primary-like units that display an initial peak of activity followed by a monotonic decline in rate to a steady-state value, and onset-sustained units that exhibit an initial peak of activity at stimulus onset followed by a low sustained activity. Compared with the chopper units, the nonchopper units tend to show longer first-spike latencies, lower peak firing rates, and more irregular sustained discharge patterns. Modeling studies show that the full range of LSO response types can be obtained from an underlying sustained chopper by varying the strength and latency of a sound-driven ipsilateral inhibition relative to that of excitation. Together, these results suggest that inhibition plays a major role in shaping the temporal discharge patterns of units in unanesthetized preparations.
机译：解剖学和药理学研究表明，横向上橄榄橄榄（LSO）从许多来源接收输入，并且LSO细胞可以改变自己的兴奋性和抑制驱动的平衡。因此，LSO细胞的正在进行的兴起反应反映了兴奋性和抑制事件的复杂相互作用，这可能受到麻醉的影响。本研究的目标是在不持续的长期Ipsilat-Eral最佳频率爆发中表征单位的单位单位的时间放电模式。将决策树基于后天割时间直方图形状进行分区LSO单元，以时间的函数和持续的放电率调整瞬时射击率。结果表明，LSO放电模式形成连续体，其中具有四个原型：持续的切碎剂，其在刺激发作时显示出两种或更多种活性的活性峰值，并且在整个反应中的速度较小，瞬态切割者可以随时间稳定的速度降低，初级样单元，显示活动的初始峰值，然后进行稳态值的单调下降，并且在刺激发作时表现出初始活性的持续单元，其次是低持续活性。与斩波装置相比，非叉叉单元倾向于显示更长的第一穗延迟，较低的峰烧制率和更不规则的持续放电模式。建模研究表明，通过改变相对于激发的声驱动的同侧抑制的强度和潜伏期，可以从底层持续的切碎器获得全系列的LSO反应类型。这些结果表明，抑制在整形在未测量的制剂中的单位的时间放电模式方面发挥着重要作用。

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