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首页> 外文期刊>Journal of Neurophysiology >Comparison of latency and rate coding for the direction of whisker deflection in the subcortical somatosensory pathway
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Comparison of latency and rate coding for the direction of whisker deflection in the subcortical somatosensory pathway

机译：对皮骨椎间盘病术路径晶须偏转方向的延迟和速率编码的比较

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摘要

The response of many neurons in the whisker somatosensory system depends on the direction in which a whisker is deflected. Although it is known that the spike count conveys information about this parameter, it is not known how important spike timing might be. The aim of this study was to compare neural codes based on spike count and first-spike latency, respectively. We extracellularly recorded single units from either the rat trigeminal ganglion (primary sensory affer-ents) or ventroposteromedial (VPM) thalamic nucleus in response to deflection in different directions and quantified alternative neural codes using mutual information. We found that neurons were diverse: some (58% in ganglion, 32% in VPM) conveyed information only by spike count; others conveyed additional information by latency. An issue with latency coding is that latency is measured with respect to the time of stimulus onset, a quantity known to the experimenter but not directly to the subject's brain. We found a potential solution using the integrated population activity as an internal timing signal: in this way, 91% of the first-spike latency information could be recovered. Finally, we asked how well direction could be decoded. For large populations, spike count and latency codes performed similarly; for small ones, decoding was more accurate using the latency code. Our findings indicate that whisker deflection direction is more efficiently encoded by spike timing than by spike count. Spike timing decreases the population size necessary for reliable information transmission and may thereby bring significant advantages in both wiring and metabolic efficiency.
机译：晶须躯体感觉系统中许多神经元的响应取决于晶须偏转的方向。虽然已知尖峰计数传达了关于该参数的信息，但是尚不知道尖峰定时可能是多么重要。本研究的目的是将分别基于尖峰计数和第一穗延迟进行比较神经电图。我们以响应于不同方向和量化的替代神经电图的偏转，从大鼠三血管神经节（主要感觉方面）或vppmeDial（VPM）丘脑核中细胞外记录单个单位。我们发现神经元多样化：一些（长神经节58％，vpm 32％）仅通过尖峰数传达信息;其他人通过延迟传达额外信息。延迟编码的问题是延迟是关于刺激发作的时间测量的，实验者已知的量，但不直接到受试者的大脑。我们发现使用集成群体活动作为内部定时信号的潜在解决方案：以这种方式，可以恢复91％的第一秒级延迟信息。最后，我们询问了方向如何解码。对于大群体，同样执行的尖峰计数和延迟码;对于小的，解码使用延迟代码更准确。我们的研究结果表明，通过峰值计时更有效地编码晶须偏转方向。尖峰定时降低了可靠信息传输所需的群体大小，从而可以在布线和代谢效率方面具有显着的优势。

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