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首页> 外文期刊>Journal of Neurophysiology >Interaction between TRPV1-expressing neurons in the hypothalamus
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Interaction between TRPV1-expressing neurons in the hypothalamus

机译：下丘脑中TRPV1表达神经元的相互作用

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摘要

Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel expressed in the peripheral and central nervous systems. TRPV1-dependent mechanisms take part in a wide range of physiological and pathophysiological pathways including the regulation of homeostatic functions. TRPV1 expression in the hypothalamus has been described as well as evidence that TRPV1-dependent excitatory inputs to hypothalamic preautonomic neurons are diminished in diabetic conditions. Here we aimed to determine the functional expression of TRPV1 in two hypothalamic nuclei known to be involved in the central control of metabolism and to test the hypothesis that TRPV1-expressing neurons receive TRPV1-expressing inputs. A mouse model (TRPV1(Cre/tdTom)) was generated to identify TRPV1-expressing cells and determine the cellular properties of TRPV1-expressing neurons in adult mice. Our study demonstrated the functional expression of TRPV1 in the dorsomedial hypothalamic nucleus and paraventricular nucleus in adult mice. Our findings revealed that a subset of TRPV1(Cre/tdTom) neurons receive TRPV1-expressing excitatory inputs, indicating direct interaction between TRPV1-expressing neurons. In addition, astrocytes likely play a role in the modulation of TRPV1-expressing neurons. In summary, this study identified specific hypothalamic regions where TRPV1 is expressed and functional in adult mice and the existence of direct connections between TRPV1(Cre/tdTom) neurons.
机译：瞬态受体潜在的香草型1（TRPV1）是在外周和中枢神经系统中表达的配体凝聚的离子通道。 TRPV1依赖机制参与各种生理和病理生理途径，包括稳​​态功能的调节。已经描述了下丘脑中的TRPV1表达以及证据表明，在糖尿病条件下降低了对下丘脑本科神经元的TRPV1依赖性输入。在这里，我们旨在确定已知涉及代谢的中央控制的TRPV1的功能表达，并测试TRPV1表达神经元接受表达TRPV1的输入的假设。产生小鼠模型（TRPV1（CRE / TDTOM））以鉴定表达TRPV1的细胞，并确定成年小鼠中TRPV1的神经元的细胞性质。我们的研究表明，成年小鼠中的背部假丘脑核和椎间囊细胞核中的TRPV1功能表达。我们的研究结果表明，TRPV1的一个子集（酶Cre / tdTom）神经元接收TRPV1表达兴奋性输入，表明TRPV1表达神经元之间的直接相互作用。此外，星形胶质细胞可能在TRPV1表达神经元的调节中发挥作用。总之，该研究确定了特定的下丘脑区域，其中TRPV1在成年小鼠中表达和功能，并且在TRPV1（CRE / TDTOM）神经元之间存在直接连接。

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