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首页> 外文期刊>Journal of Neurophysiology >Role of astroglia in diet-induced central neuroplasticity
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Role of astroglia in diet-induced central neuroplasticity

机译：星形虎症在饮食诱导的中枢性神经塑性中的作用

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摘要

Obesity, characterized by increased adiposity that develops when energy intake outweighs expenditure, is rapidly becoming a serious health crisis that affects millions of people worldwide and is associated with severe comorbid disorders including hypertension, cardiovascular disease, and type II diabetes. Obesity is also associated with the dysregulation of central neurocircuits involved in the control of autonomic, metabolic, and cognitive functions. Systemic inflammation associated with diet-induced obesity (DIO) has been proposed to be responsible for the development of these comorbidities as well as the dysregulation of central neurocircuits. A growing body of evidence suggests, however, that exposure to a high-fat diet (HFD) may cause neuroinflammation and astroglial activation even before systemic inflammation develops, which may be sufficient to cause dysregulation of central neurocircuits involved in energy homeostasis before the development of obesity. The purpose of this review is to summarize the current literature exploring astroglial-dependent modulation of central circuits following exposure to HFD and DIO, including not only dysregulation of neurocircuits involved in energy homeostasis and feeding behavior, but also the dysregulation of learning, memory, mood, and reward pathways.
机译：肥胖，其特点是增加肥胖当能量摄入远远超过支出，在发展，正在迅速成为一个严重的健康危机是影响全世界数百万人，并有严重合并症的疾病，包括高血压，心血管疾病和II型糖尿病。肥胖症也与参与自主，代谢，和认知功能的控制中心的神经电路的失调相关。饮食诱导的肥胖（DIO）相关的全身性炎症已经提出来负责这些合并症的发展以及中央神经电路的失调。越来越多的证据体所暗示的，然而，在暴露于高脂肪膳食（HFD）可能会导致神经炎症和全身性炎症的发展甚至在星形胶质细胞的激活，这可足以发展之前参与能量稳态中央的神经电路的原因失调肥胖。该评价的目的是总结目前的文献探索在暴露于HFD和DIO中央电路，不仅包括涉及能量体内平衡和摄食行为的神经电路的失调的星形胶质细胞依赖性调制，而且还学习，记忆，情绪失调和奖励的途径。

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