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首页> 外文期刊>Journal of Neurophysiology >Functional brain stem circuits for control of nose motion
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Functional brain stem circuits for control of nose motion

机译：用于控制鼻子运动的功能性脑干电路

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Rodents shift their nose from side to side when they actively explore and lateralize odors in the space. This motor action is driven by a pair of muscles, the deflector nasi. We studied the premotor control of this motion. We used replication-competent rabies virus to transsynaptically label inputs to the deflector nasi muscle and find putative premotor labeling throughout the parvocellular, intermediate, and gigantocellular reticular formations, as well as the trigeminal nuclei, pontine reticular formation, midbrain reticular formation, red nucleus. and superior colliculus. Two areas with extensive labeling were analyzed for their impact on nose movement. One area is in the reticular formation caudal to the facial motor nucleus and is denoted the nose retro-facial area. The second is in the caudal part of the intermediate reticular region near the oscillator for whisking (the nose IRt). Functionally, we find that optogenetic activation of glutamatergic cells in both areas drives deflection of the nose. Ablation of cells in the nose retrofacial area, but not the nose IRt, impairs movement of the nose in response to the presentation of odorants but otherwise leaves movement unaffected. These data suggest that the nose retrofacial area is a conduit for a sensory-driven orofacial motor action. Furthermore, we find labeling of neurons that are immediately upstream of premotor neurons in the preBotzinger complex that presumably synchronizes a small, rhythmic component of nose motion to breathing.
机译：当他们积极探索和横向化空间中的气味时，啮齿动物从一边转移到一侧。该电机动作由一对肌肉驱动，偏转器NASI。我们研究了对此运动的热调控。我们使用复制竞争性狂犬病病毒来跨突触地标记导线肌肌肉，并在整个术细胞，中间体和缩窄细胞网状形成过程中找到推定的热球标记，以及三核核，猪猪网状形成，中脑网状形成，红色核。和优越的小集。分析了具有广泛标记的两个区域，以造成鼻子运动的影响。一个区域位于面部电机细胞核的网状形成尾部，并表示鼻子复古面积。第二个是振荡器附近的中间网状区域的尾部部分，用于搅拌（鼻葵IRT）。在功能上，我们发现两个领域在两个领域的谷胱甘肽细胞的瞳孔体激活驱动鼻子的偏转。蒸煮鼻子出口区域中的细胞，但不是鼻子IRT，响应呼吸剂的呈递而损害鼻子的运动，但其他叶子不受影响。这些数据表明，鼻出翅区域是用于感觉驱动的牙品电动机作用的导管。此外，我们发现在预突出的Zinger复合物中立即上游的神经元标记，其可能会使鼻子运动的小型有节奏成分与呼吸同步。

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