...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Loose coupling between SK and P/Q-type Ca2+ channels in cartwheel cells of the dorsal cochlear nucleus
【24h】

Loose coupling between SK and P/Q-type Ca2+ channels in cartwheel cells of the dorsal cochlear nucleus

机译：SK和P / Q型CA2 +通道之间的松散耦合，背部耳蜗核的电车电池

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Small-conductance Ca2+-activated K+ (SK) and large-conductance voltage- and Ca2+-activated K+ (BK) channels are Ca2+-activated K+ channels that control action potential firing in diverse neurons in the brain. In cartwheel cells of the dorsal cochlear nucleus, blockade of either channel type leads to excessive production of spike bursts. In the same cells, P/Q-type Ca2+ channels in plasma membrane and ryanodine receptors in endoplasmic reticulum supply Ca2+ to BK channels through Ca2+ nanodomain signaling. In this study, voltage-clamp experiments were performed in cartwheel cells in mouse brain slices to examine the Ca2+ signaling pathways underlying activation of SK channels. As with BK channels, SK channels required the activity of P/Q-type Ca2+ channels. However, this signaling occurred across Ca2+ micro- rather than nanodomain distances and was independent of Ca2+ release from endoplasmic reticulum. These differential modes of activation may lead to distinct time courses of the two K+ currents and therefore control excitability of auditory neurons across different timescales.
机译：小电导钙激活K +（SK）和大电导电压 - 和Ca2 +激活的K +（BK）通道是钙激活K +通道，在大脑中的神经元不同的控制动作电位发放。在背耳蜗核，要么沟道型导致过度产生尖峰脉冲串的封锁侧翻细胞。在相同的细胞中，P / Q型钙离子通过钙离子nanodomain信令质膜和兰尼碱受体的内质网的Ca2供应到+ BK通道的通道。在这项研究中，电压钳实验在侧翻细胞在小鼠脑切片进行检查的Ca2 +底层SK通道的激活信号转导途径。与BK通道，SK通道所需P / Q型钙离子通道的活性。然而，这种信号跨越的Ca2 +发生微而非nanodomain距离和独立是从内质网Ca2 +释放。激活的这些差分模式可导致两个K +电流的不同时间过程，并因此控制跨越不同时间尺度听觉神经元的兴奋性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号