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首页> 外文期刊>Journal of Neurophysiology >Three-dimensional tuning of head direction cells in rats
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Three-dimensional tuning of head direction cells in rats

机译：大鼠头部方向细胞的三维调谐

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Head direction (HD) cells fire when the animal faces that cell's preferred firing direction (PFD) in the horizontal plane. The PFD response when the animal is oriented outside the earth-horizontal plane could result from cells representing direction in the plane of locomotion or as a three-dimensional (3D), global-referenced direction anchored to gravity. To investigate these possibilities, anterodorsal thalamic HD cells were recorded from restrained rats while they were passively positioned in various 3D orientations. Cell responses were unaffected by pitch or roll up to similar to 90 degrees from the horizontal plane. Firing was disrupted once the animal was oriented 90 degrees away from the horizontal plane and during inversion. When rolling the animal around the earth-vertical axis, cells were active when the animal's ventral surface faced the cell's PFD. However, with the rat rolled 90 degrees in an ear-down orientation, pitching the rat and rotating it around the vertical axis did not produce directionally tuned responses. Complex movements involving combinations of yaw-roll. but usually not yaw-pitch, resulted in reduced directional tuning even at the final upright orientation when the rat had full visual view of its environment and was pointing in the cell's PFD. Directional firing was restored when the rat's head was moved back-and-forth. There was limited evidence indicating that cells contained conjunctive firing with pitch or roll positions. These findings suggest that the brain's representation of directional heading is derived primarily from horizontal canal information and that the LID signal is a 3D gravity-referenced signal anchored to a direction in the horizontal plane.
机译：当动物面临水平平面中的电池的优选烧制方向（PFD）时，头部方向（HD）细胞发生火焰。当动物在地面水平平面外面取向时的PFD响应可能由表示在运动平面中的细胞或作为三维（3D），锚固到重力的全局引用方向的细胞导致。为了探讨这些可能性，从受约束的大鼠记录亚腔丘脑HD细胞，同时它们被动地以各种3D取向定位。细胞应答不受间距的影响或从水平平面卷起到90度。一旦动物定向，射击就会破坏，远离水平平面90度，并在反转期间。当动物围绕地球垂直轴线滚动动物时，当动物的腹侧表面面向细胞的PFD时，细胞是有效的。然而，随着大鼠在耳下方向上滚动90度，俯仰大鼠并在垂直轴线周围旋转它没有产生定向调谐的响应。涉及偏航卷组合的复杂运动。但通常不是偏航的，导致在大鼠对其环境的完全视觉视图并指向细胞的PFD时，即使在最终的直立方向上也导致定向调整。当老鼠的头部移动时，恢复定向射击。有限的证据表明细胞含有俯仰或卷位置的结合烧制。这些发现表明，大脑的方向性标题的表示主要来自水平管信息，并且盖子信号是锚定到水平面中的方向的3D重力引用信号。

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