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首页> 外文期刊>Journal of Neurophysiology >Changes in motor-evoked potential latency during grasping after tetraplegia
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Changes in motor-evoked potential latency during grasping after tetraplegia

机译：四川省掌握后电动机诱发电位延迟的变化

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The corticospinal pathway contributes to the control of grasping in intact humans. After spinal cord injury (SCI), there is an extensive reorganization in the corticospinal pathway; however, its contribution to the control of grasping after the injury remains poorly understood. We addressed this question by using transcranial magnetic stimulation (TMS) over the hand representation of the motor cortex to elicit motor-evoked potentials (MEPs) in an intrinsic finger muscle during precision grip and power grip with the TMS coil oriented to induce currents in the brain in the latero-medial (LM) direction to activate corticospinal axons directly and in the posterior-anterior (PA) and anterior-posterior (AP) directions to activate the axon indirectly through synaptic inputs in humans with and without cervical incomplete SCI. We found prolonged MEP latencies in all coil orientations in both tasks in SCI compared with control subjects. The latencies of MEPs elicited by AP relative to LM stimuli were consistently longer during power compared with precision grip in controls and SCI subjects. In contrast, PA relative to LM MEP latencies were similar between tasks across groups. Central conduction time of AP MEPs was prolonged during power compared with precision grip in controls and SCI participants. Our results support evidence indicating that inputs activated by AP and PA currents are engaged to a different extent during fine and gross grasping in humans with and without SCI.
机译：皮质脊柱途径有助于控制完整的人类抓住。在脊髓损伤（SCI）后，皮质脊柱途径存​​在广泛的重组;然而，它对伤害后对掌握控制的贡献仍然很清楚。我们通过在精密抓地力和动力抓地力期间使用电动机皮层的手持式磁刺激（TMS）在机动皮层的手上表示，在精确的握把和电力握力，以导向的TMS线圈引起电流的电流脑中脑中的脑部直接和前后（PA）和前后（AP）方向上和前后（AP）方向激活皮质枢轴，以间接地通过具有宫颈不完全SCI的人类的突触输入间接激活轴突。与对照科目相比，我们在SCI中的任务中找到了延长的MEP延迟。与LM刺激引发的MEPS相对于LM刺激引起的MEPS延迟在功率中始终延长，与控制和SCI受试者的精确夹具相比。相反，PA相对于LM MEP延迟在跨组的任务之间类似。与控制和SCI参与者的精确夹具相比，在动力下延长了AP MEP的中央导通时间。我们的成果支持证据表明，AP和PA电流激活的投入在良好和粗略的人类掌握和无SCI的情况下啮合。

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