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首页> 外文期刊>Journal of Neurophysiology >Between-hand coupling during response inhibition
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Between-hand coupling during response inhibition

机译：在反应抑制期间的手耦合

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Response inhibition reflects the process of terminating inappropriate preplanned or ongoing movements. When one hand is cued to stop after preparing a bimanual response (Partial trial), there is a substantial delay on the responding side. This delay is termed the interference effect and identifies a constraint that limits selective response inhibition. gamma-Aminobutyric acid (GABA)-mediated networks within primary motor cortex (M1) may have distinct roles during response inhibition. In this study we examined whether the interference effect is the consequence of between-hand "coupling" into a unitary response and whether this is reflected in GABAergic intracortical inhibition within M1. Eighteen healthy right-handed participants performed a bimanual synchronous and asynchronous anticipatory response inhibition task. Electromyo-graphic recordings were obtained from the first dorsal interosseous muscle bilaterally. Motor evoked potentials were elicited by single-and paired-pulse transcranial magnetic stimulation over right M1. As expected, Go trial performance was better with the synchronous compared with the asynchronous version of the task. Paradoxically, response delays during Partial trials were longer with the synchronous compared with the asynchronous task. Although task difficulty did not modulate GABAergic intracortical inhibition, there was a trend for between-hand coupling on asynchronous trials to be associated with greater GABA B receptor-mediated inhibition and lesser recruitment of GABA A receptor-mediated inhibition. The novel findings indicate that the interference effect is in part a consequence of between-hand coupling into a unitary response during movement preparation. The ability to respond independently with the two hands may rely on modulation of distinct inhibitory processes.
机译：反应抑制反映了终止不适当的预先或正在进行的运动的过程。当一只手被提示在制备生物响应（部分试验）后停止时，响应侧存在大量延迟。该延迟被称为干扰效果，并识别限制选择性响应抑制的约束。在初级电动机皮质（M1）内的γ-氨基丁酸（GABA）介导的网络可能在响应抑制期间具有不同的作用。在这项研究中，我们检查了干扰效果是否是将手中“耦合”到整体响应中的结果，以及是否反映在M1内的胃肠杆菌内抑制中。十八次健康的右手参与者进行了一种生理同步和异步的预期响应抑制任务。电摩托图形记录是双侧的第一个背侧肌肉获得的。通过右M1，通过单次和配对脉冲经颅磁刺激引发电动机诱发电位。正如预期的那样，与任务的异步版相比，Go试用性能更好。与异步任务相比，部分试验期间，部分试验期间的响应延迟较长。虽然任务难度没有调节胃肠杆菌性抑制，但在异步试验中呈现出与更高的GABA B受体介导的抑制和较小的GABA募集的受体介导的抑制作用的趋势。该新发现表明，干扰效果部分地是在运动准备期间的手中耦合到整体响应的后果。用两只手独立响应的能力可以依赖于不同抑制过程的调节。

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