...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Regional brain stem activations during capsaicin inhalation using functional magnetic resonance imaging in humans
【24h】

Regional brain stem activations during capsaicin inhalation using functional magnetic resonance imaging in humans

机译：利用人类功能磁共振成像在辣椒素吸入期间的区域脑干激活

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Coughing is an airway protective behavior elicited by airway irritation. Animal studies show that airway sensory information is relayed via vagal sensory fibers to termination sites within dorsal caudal brain stem and thereafter relayed to more rostral sites. Using functional magnetic resonance imaging (fMRI) in humans, we previously reported that inhalation of the tussigenic stimulus capsaicin evokes a perception of airway irritation ("urge to cough") accompanied by activations in a widely distributed brain network including the primary sensorimotor, insular, prefrontal, and posterior parietal cortices. Here we refine our imaging approach to provide a directed survey of brain stem areas activated by airway irritation. In 15 healthy participants, inhalation of capsaicin at a maximal dose that elicits a strong urge to cough without behavioral coughing was associated with activation of medullary regions overlapping with the nucleus of the solitary tract, paratrigeminal nucleus, spinal trigeminal nucleus and tract, cardiorespiratory regulatory areas homologous to the ventrolateral medulla in animals, and the midline raphe. Interestingly, the magnitude of activation within two cardiorespiratory regulatory areas was positively correlated (r(2) = 0.47, 0.48) with participants' subjective ratings of their urge to cough. Capsaicin-related activations were also observed within the pons and midbrain. The current results add to knowledge of the representation and processing of information regarding airway irritation in the human brain, which is pertinent to the pursuit of novel cough therapies.
机译：咳嗽是呼吸道刺激引发的气道保护行为。动物研究表明，气道感官信息通过迷入感觉纤维转发到背部尾部脑干中的终止位点，然后转移到更多的敌管位点。在人类使用功能性磁共振成像（fMRI），我们以前报道呼吸道刺激的tussigenic刺激辣椒素唤起了人们感知的是吸入（“冲动咳嗽”）在广泛分布的脑网络，包括初级感觉，孤芳自赏伴随着激活，前额外和后部皮质。在这里，我们优化了我们的成像方法，以提供对气道刺激激活的脑干区域的定向调查。在15名健康的参与者中，在最大剂量的最大剂量中吸入辣椒素，在没有行为咳嗽的情况下引发强烈的咳嗽，与孤立菌，副核，脊髓三角细胞核和道核，心肺部核心，心肺部核心的髓鞘区域重叠的激活有关对动物的腹外侧髓质和中线拉皮的同源。有趣的是，两个心肺监管区域的激活程度正相关（R（2）= 0.47,0.48），与参与者的主观评级咳嗽的主观评级。在PON和中脑内也观察到辣椒素相关的激活。目前的结果增加了对人脑中气道刺激的信息的表示和处理的知识，这与追求新型咳嗽疗法有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号