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Contrast gain control in mouse auditory cortex

机译：鼠标听觉皮层中的对比度增益控制

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The neocortex is thought to employ a number of canonical computations, but little is known about whether these computations rely on shared mechanisms across different neural populations. In recent years, the mouse has emerged as a powerful model organism for the dissection of the circuits and mechanisms underlying various aspects of neural processing and therefore provides an important avenue for research into putative canonical computations. One such computation is contrast gain control, the systematic adjustment of neural gain in accordance with the contrast of sensory input. which helps to construct neural representations that are robust to the presence of background stimuli. Here, we characterized contrast gain control in the mouse auditory cortex. We performed laminar extracellular recordings in the auditory cortex of the anesthetized mouse while varying the contrast of the sensory input. We observed that an increase in stimulus contrast resulted in a compensatory reduction in the gain of neural responses, leading to representations in the mouse auditory cortex that are largely contrast invariant. Contrast gain control was present in all cortical layers but was found to be strongest in deep layers, indicating that intracortical mechanisms may contribute to these gain changes. These results lay a foundation for investigations into the mechanisms underlying contrast adaptation in the mouse auditory cortex.
机译：Neocortex被认为采用了许多规范计算，但是关于这些计算是否依赖于不同神经群体的共享机制很少。近年来，小鼠作为一种强大的模型生物体，用于解剖该电路和机制神经处理的各个方面的各个方面，因此为推定规范计算提供了重要的途径。一种这样的计算是对比度增益控制，根据感觉输入的对比度来系统调整神经增益。这有助于构建对存在背景刺激的存在的神经表示。在这里，我们在鼠标听觉皮层中表征了对比度增益控制。我们在麻醉的小鼠的听觉皮层中进行了层状细胞外记录，同时改变了感官输入的对比度。我们观察到刺激对比度的增加导致神经反应增益的补偿性降低，导致小鼠听觉皮层的表示，这在很大程度上是对比不变的。在所有皮质层中存在对比度增益控制，但发现在深层中最强，表明肠内机制可能有助于这些增益变化。这些结果奠定了对鼠标听觉皮质中对比调整的机制的研究基础。

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