Experience-related reductions of myelin and axon diameter in adulthood

Lazari Alberto; Koudelka Sigrid; Sampaio-Baptista Cassandra

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Experience-related reductions of myelin and axon diameter in adulthood

机译：经验相关的髓鞘和阿隆直径在成年期

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The production of new myelin has been highlighted as an underappreciated mechanism of brain plasticity, but whether plastic decreases in myelin also happen in the adult brain has been largely unexplored. Recently, Sinclair et al. (Sinclair JS, Fischl MJ, Alexandrova O, HeB M, Grothe B, L.eibold C, and Kopp-Scheinpflug C. J Neurosci 37: 8239-8255, 2017) have shown that auditory deprivation can lead to decrease in myelination and axon caliber even in healthy adulthood. These findings show that activity-regulated myelination is more complex than previously thought and expand our knowledge of how adult brain plasticity could operate on a cellular level.

机译：新髓鞘的生产被突出显示为脑可塑性的低估机制，但霉菌素是否在成年大脑中发生的霉菌素也在很大程度上是未开发的。最近，Sinclair等人。（Sinclair Js，Fischl MJ，Alexandrova O，Heb M，Grothe B，L.Eibold C和Kopp-Scheinpflug C.J Neurosci 37：8239-8255,2017）表明，听觉剥夺可能导致髓鞘和轴突下降口径甚至在健康的成年期。这些调查结果表明，活动调节的髓鞘活动比以前认为更复杂，并扩大了我对成年脑可塑性如何在蜂窝水平上运行的了解。

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来源
《Journal of Neurophysiology》 |2018年第4期|共4页
作者
Lazari Alberto; Koudelka Sigrid; Sampaio-Baptista Cassandra;
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作者单位

Univ Oxford Wellcome Trust Doctoral Programme Neurosci Oxford England;

Univ Edinburgh Ctr Discovery Brain Sci Edinburgh Midlothian Scotland;

Univ Oxford Oxford Wellcome Ctr Integrat Neuroimaging Nuffield Dept Clin Neurosci FMRIB Oxford;

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正文语种 eng
中图分类人体生理学;
关键词
auditory processing; conduction velocity; myelination; plasticity; sensory deprivation;

机译：听觉处理;传导速度;髓鞘;可塑性;感官剥夺;

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专利

1. Experience-related reductions of myelin and axon diameter in adulthood [J] . Lazari Alberto, Koudelka Sigrid, Sampaio-Baptista Cassandra Journal of Neurophysiology . 2018,第4期

机译：经验相关的髓鞘和阿隆直径在成年期
2. Axon Diameters and Myelin Content Modulate Microscopic Fractional Anisotropy at Short Diffusion Times in Fixed Rat Spinal Cord [J] . Shemesh Noam Frontiers in Physics . 2018,第4期

机译：轴突直径和髓磷脂含量调节固定大鼠脊髓短扩散时间的微观分数各向异性。
3. Relation between myelin area and axon diameter in the aortic depressor nerve of spontaneously hypertensive rats. [J] . Fazan VP, Salgado HC, dos Reis GC, Journal of Neuroscience Methods . 2005,第2期

机译：自发性高血压大鼠主动脉下垂神经髓鞘面积与轴突直径的关系。
4. Multi-modal Measurement of the Myelin-to-Axon Diameter g-ratio in Preterm-born Neonates and Adult Controls [C] . Andrew Melbourne, Zach Eaton-Rosen, Enrico De Vita, International conference on medical imaging computing and computer-assisted intervention . 2014

机译：早产新生儿和成人对照中髓磷脂与轴突直径g比率的多峰测量
5. Mechanisms of Central Axon and Myelin Injury Using Advanced Morphological and Biochemical Characterization. [D] . Teo, Wulin. 2015

机译：使用高级形态学和生化特征的中枢轴突和髓鞘损伤的机制。
6. Axon diameter and myelin sheath thickness in nerve fibres of the ventral spinal root of the seventh lumbar nerve of the adult and developing cat. [O] . C H Berthold, I Nilsson, M Rydmark 1983

机译：成年和发育中猫的第七个腰神经腹侧脊髓根神经纤维的轴突直径和髓鞘厚度。
7. Human intraretinal myelination: Axon diameters and axon/myelin thickness ratios [O] . Thomas FitzGibbon, Zoran Nestorovski 2013

机译：人视网膜内髓鞘形成：轴突直径和轴突/髓鞘厚度比

Experience-related reductions of myelin and axon diameter in adulthood

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