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首页> 外文期刊>Journal of Neurophysiology >Phase-amplitude coupling within the anterior thalamic nuclei during seizures
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Phase-amplitude coupling within the anterior thalamic nuclei during seizures

机译：在癫痫发作期间前丘脑核内的相位幅度耦合

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Cross-frequency phase-amplitude coupling (cfPAC) subserves an integral role in the hierarchical organization of interregional neuronal communication and is also expressed by epileptogenic cortex during seizures. Here, we sought to characterize patterns of cfPAC expression in the anterior thalamic nuclei during seizures by studying extra-operative recordings in patients implanted with deep brain stimulation electrodes for intractable epilepsy. Nine seizures from two patients were analyzed in the peri-ictal period. CfPAC was calculated using the modulation index and interregional functional connectivity was indexed using the phase-locking value. Statistical analysis was performed within subjects on the basis of nonparametric permutation and corrected with Gaussian field theory. Five of the nine analyzed seizures demonstrated significant cfPAC. Significant cfPAC occurred during the pre-ictal and ictal periods in three seizures, as well as the postictal windows in four seizures. The preferred phase at which cfPAC occurred differed 1) in space, between the thalami of the epileptogenic and nonepileptogenic hemispheres; and 2) in time, at seizure termination. The anterior thalamic nucleus of the epileptogenic hemisphere also exhibited altered interregional phase-locking synchrony concurrent with the expression of cfPAC. By analyzing extraoperative recordings from the anterior thalamic nuclei, we show that cfPAC associated with altered interregional phase synchrony is lateralized to the thalamus of the epileptogenic hemisphere during seizures. Electrophysiological differences in cfPAC, including preferred phase of oscillatory interactions may be further investigated as putative targets for individualized neuromodulation paradigms in patients with drug-resistant epilepsy.
机译：横频相位振幅耦合（CFPAC）为区域间神经元通信的分层组织中保护积分作用，并且也被癫痫发作期间的癫痫皮质表达。在这里，我们通过研究植入深脑刺激电极的患者植入癫痫患者的患者的特性记录来表征癫痫发作期间的CFPAC表达的模式。来自两名患者的9个癫痫发作在Peri-ICTAL期间分析。使用调制指数计算CFPAC，使用锁相值索引索引区域间功能连接。基于非参数置换和通过高斯场理论校正的受试者内进行统计分析。九个分析的癫痫发作中的五个表现出显着的CFPAC。在三次癫痫发作前的ITAR和ICTAL期间发生了重要的CFPAC，以及四次癫痫发作的后窗。 CFPAC发生的优选阶段在癫痫发生和非渗透半球的丘脑之间存在差异为1）; 2）及时，在癫痫发作。癫痫发生半球的前丘脑核也表现出改变的区域间锁相同步并发与CFPAC的表达。通过分析前丘脑核的异常录音，我们表明与改变的区域间相同步的CFPAC潜在癫痫发作期间癫痫术半球的丘脑。 CFPAC中的电生理学差异，包括抗毒性癫痫患者中个体化神经调节范例的诱发靶标的辐射相互作用的优选阶段。

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