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首页> 外文期刊>Journal of Neurophysiology >Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells
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Diversity in spatial scope of contrast adaptation among mouse retinal ganglion cells

机译：小鼠视网膜神经节细胞对比度适应空间范围的多样性

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Retinal ganglion cells adapt to changes in visual contrast by adjusting their response kinetics and sensitivity. While much work has focused on the time scales of these adaptation processes, less is known about the spatial scale of contrast adaptation. For example, do small, localized contrast changes affect a cell's signal processing across its entire receptive field? Previous investigations have provided conflicting evidence, suggesting that contrast adaptation occurs either locally within subregions of a ganglion cell's receptive field or globally over the receptive field in its entirety. Here, we investigated the spatial extent of contrast adaptation in ganglion cells of the isolated mouse retina through multielectrode-array recordings. We applied visual stimuli so that ganglion cell receptive fields contained regions where the average contrast level changed periodically as well as regions with constant average contrast level. This allowed us to analyze temporal stimulus integration and sensitivity separately for stimulus regions with and without contrast changes. We found that the spatial scope of contrast adaptation depends strongly on cell identity, with some ganglion cells displaying clear local adaptation, whereas others, in particular large transient ganglion cells, adapted globally to contrast changes. Thus, the spatial scope of contrast adaptation in mouse retinal ganglion cells appears to be cell-type specific. This could reflect differences in mechanisms of contrast adaptation and may contribute to the functional diversity of different ganglion cell types.
机译：视网膜神经节细胞通过调节它们的响应动力学和敏感性来适应视觉对比的变化。虽然很多工作都集中在这些适应过程的时间尺度上，但是关于对比度自适应的空间比例所知的较少。例如，DOM，局部对比度变化会影响其整个接收领域的小区的信号处理？以前的调查提供了相互矛盾的证据，这表明对睫状体适应在整个接收领域的接受领域或全球范围内发生局部地发生。在这里，我们通过多电极阵列记录调查了孤立的小鼠视网膜的神经节细胞的对比度适应的空间程度。我们应用视觉刺激，使神经节细胞接收领域包含区域的区域，其中平均对比度水平周期性以及具有恒定平均对比度水平的区域。这使我们可以分析时间刺激集成和敏感性，以分别用于刺激区域，而没有对比变化。我们发现对比度适应的空间范围依赖于细胞同一性，一些神经节细胞显示出清晰的局部适应，而其他神经节细胞尤其在大型瞬态神经节细胞，则全局适应形成对比变化。因此，小鼠视网膜神经节细胞中对比度适应的空间范围似乎是特定的细胞类型。这可能反映了对比度适应机制的差异，并且可能有助于不同神经节细胞类型的功能多样性。

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