Association of copeptin, a surrogate marker of arginine vasopressin, with cerebral vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage

Fernandez Sandra J.; Barakat Ibraham; Ziogas James; Frugier Tony; Stylli Stanley S.; Laidlaw John D.; Kaye Andrew H.; Adamides Alexios A.

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Association of copeptin, a surrogate marker of arginine vasopressin, with cerebral vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage

机译：Copeptin，Agennine Vasopressin的替代标志物，具有脑血管痉挛和动脉瘤蛛网膜下腔出血后脑血管痉挛和缺血性神经系统缺陷

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OBJECTIVE Delayed ischemic neurological deficit (DIND) is a leading cause of mortality and morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Arginine vasopressin (AVP) is a hormone released by the posterior pituitary. It is known to cause cerebral vasoconstriction and has been implicated in hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion. Direct measurement of AVP is limited by its short half-life. Copeptin, a cleavage product of the AVP precursor protein, was therefore used as a surrogate marker for AVP. This study aimed to investigate the temporal relationship between changes in copeptin concentrations and episodes of DIND and hyponatremia.

机译：目的延迟缺血性神经缺陷（Dind）是动脉瘤蛛网膜瘤出血（ASAH）后死亡率和发病率的主要原因。精氨酸血管素（AVP）是后脑脊上释放的激素。已知造成脑血管收缩，并涉及次乳腺血症的副血症血症患者，其患者的不适当性激素分泌的综合征。 AVP的直接测量受其短半衰期的限制。因此，Copeptin（AVP前体蛋白的切割产物）因此用作AVP的替代标记物。本研究旨在探讨Copeptin浓度和Dind和Hyponraidia发作之间的时间关系。

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来源
《Journal of neurosurgery.》 |2019年第5期|共7页
作者
Fernandez Sandra J.; Barakat Ibraham; Ziogas James; Frugier Tony; Stylli Stanley S.; Laidlaw John D.; Kaye Andrew H.; Adamides Alexios A.;
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作者单位

Univ Melbourne Fac Med Dent &

Hlth Sci Melbourne Vic Australia;

Univ Melbourne Fac Med Dent &

Hlth Sci Melbourne Vic Australia;

Univ Melbourne Dept Pharmacol &

Therapeut Melbourne Vic Australia;

Univ Melbourne Dept Pharmacol &

Therapeut Melbourne Vic Australia;

Univ Melbourne Dept Surg Melbourne Vic Australia;

Univ Melbourne Dept Surg Melbourne Vic Australia;

Univ Melbourne Dept Surg Melbourne Vic Australia;

Univ Melbourne Dept Surg Melbourne Vic Australia;

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正文语种 eng
中图分类头部及神经外科学;
关键词
arginine vasopressin; cerebral vasospasm; copeptin; delayed ischemic neurologic deficit; hyponatremia; syndrome of inappropriate antiduretic hormone secretion; vascular disorders;

机译：精氨酸血管加压素;脑血管痉挛;Copeptin;延迟缺血性神经缺陷;低钠血症;不适当的抗性激素分泌的综合征;血管障碍;

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1. Association of copeptin, a surrogate marker of arginine vasopressin, with cerebral vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage [J] . Fernandez Sandra J., Barakat Ibraham, Ziogas James, Journal of neurosurgery. . 2019,第5期

机译：Copeptin，Agennine Vasopressin的替代标志物，具有脑血管痉挛和动脉瘤蛛网膜下腔出血后脑血管痉挛和缺血性神经系统缺陷
2. Endothelin concentrations in patients with aneurysmal subarachnoid hemorrhage. Correlation with cerebral vasospasm, delayed ischemic neurological deficits, and volume of hematoma. [J] . Seifert V, Loffler BM, Zimmermann M, Journal of neurosurgery. . 1995,第1期

机译：动脉瘤蛛网膜下腔出血患者的内皮素浓度。与脑血管痉挛，局部缺血性神经功能缺损和血肿量相关。
3. Effects of acute treatment with pravastatin on cerebral vasospasm, autoregulation, and delayed ischemic deficits after aneurysmal subarachnoid hemorrhage: a phase II randomized placebo-controlled trial. [J] . Tseng MY, Czosnyka M, Richards H, Stroke: A Journal of Cerebral Circulation . 2005,第8期

机译：普伐他汀急性治疗对动脉瘤性蛛网膜下腔出血后脑血管痉挛，自体调节和缺血性迟发迟缓的影响：II期随机安慰剂对照试验。
4. Section on Cerebrovascular Surgery: Galbraith Award: Endothelial Nitric Oxide Synthase (eNOS) and Heme Oxygenase-1 (HO-1) Gene Polymorphisms Predict Susceptibility to Aneurysmal Subarachnoid Hemorrhage (SAH) and Post-SAH Cerebral Vasospasm [C] . Vini G. Khurana, Youvraj R. Sohni, Wells I. Mangrum Congress of Neurological Surgeons . 2004

机译：关于脑血管外科的部分：GALBraith奖：内皮一氧化氮合酶（ENOS）和血红素氧酶-1（HO-1）基因多态性预测动脉瘤蛛网膜下腔（SAH）和后脑血管痉挛的易感性
5. The effect of head of bed elevation on cerebrovascular dynamics in mild or moderate cerebral vasospasm following aneurysmal subarachnoid hemorrhage. [D] . Blissitt, Patricia Ann. 2002

机译：床头抬高对动脉瘤蛛网膜下腔出血后轻度或中度脑血管痉挛的脑血管动力学的影响。
6. Role of Endothelin-1 in Human Aneurysmal Subarachnoid Hemorrhage: Associations with Vasospasm and Delayed Cerebral Ischemia [O] . Bhavani P. Thampatty, Paula R. Sherwood, Matthew J. Gallek, -1

机译：内皮素-1在人动脉瘤性蛛网膜下腔出血中的作用：血管痉挛和延迟脑缺血的关联
7. Effects of Acute Treatment With Pravastatin on Cerebral Vasospasm, Autoregulation, and Delayed Ischemic Deficits After Aneurysmal Subarachnoid Hemorrhage [O] . Ming-Yuan Tseng, Marek Czosnyka, Hugh Richards, 2005

机译：普伐他汀对脑血管痉挛，自身血管痉挛性血管痉挛性出血后脑血管痉挛，自疗法及延迟缺血性缺血的影响

Association of copeptin, a surrogate marker of arginine vasopressin, with cerebral vasospasm and delayed ischemic neurologic deficit after aneurysmal subarachnoid hemorrhage

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