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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Investigating the effect of magnetic dipole-dipole interaction on magnetic particle spectroscopy: implications for magnetic nanoparticle-based bioassays and magnetic particle imaging
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Investigating the effect of magnetic dipole-dipole interaction on magnetic particle spectroscopy: implications for magnetic nanoparticle-based bioassays and magnetic particle imaging

机译：研究磁偶极偶偶极相互作用对磁粒子光谱的影响：磁性纳米粒子基生物测定和磁颗粒成像的影响

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摘要

Superparamagnetic iron oxide nanoparticles (SPIONs), with comparable size to biomolecules (such as proteins, nucleic acids, etc) and unique magnetic properties, good biocompatibility, low toxicity, potent catalytic behavior, are promising candidates for many biomedical applications. There is one property present in most SPION systems, yet it has not been fully exploited, which is the dipole-dipole interaction (also called dipolar interaction) between the SPIONs. It is known that the magnetic dynamics of an ensemble of SPIONs are substantially influenced by the dipolar interactions. However, the exact way it affects the performance of magnetic particle-based bioassays and magnetic particle imaging (MPI) is still an open question. The purpose of this paper is to give a partial answer to this question. This is accomplished by numerical simulations on the dipolar interactions between two nearby SPIONs and experimental measurements on an ensemble of SPIONs using our lab-based magnetic particle spectroscopy (MPS) system.
机译：超顺磁性氧化铁纳米颗粒（栓塞），具有与生物分子（如蛋白质，核酸等）和独特的磁性，良好的生物相容性，低毒性，有效的催化行为的相当大小是许多生物医学应用的候选者。大多数Spion系统中存在一个物业，但它尚未完全利用，这是散膜之间的偶极偶极交互（也称为双极交互）。众所周知，散块的集合的磁动力学基本上受到偶极相互作用的影响。然而，它影响磁性粒子基生物测定和磁性粒子成像（MPI）的性能的确切方式仍然是一个打开的问题。本文的目的是给出这个问题的部分答案。这是通过在使用我们的实验室磁粒子谱（MPS）系统的两个附近的散热和散块的集合的偶极相互作用的数值模拟来实现。

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