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首页> 外文期刊>Journal of Physics, D. Applied Physics: A Europhysics Journal >Low-field and high-field magnetic resonance contrast imaging of magnetoferritin as a pathological model system of iron accumulation
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Low-field and high-field magnetic resonance contrast imaging of magnetoferritin as a pathological model system of iron accumulation

机译：磁铁脲素的低场和高场磁共振对比度成像作为铁堆的病理模型系统

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Various pathological processes including neurodegenerative disorders are associated with the accumulation of iron, while it is believed that a precursor of iron accumulation is ferritin. Physiological ferritin is due to low relaxivity, which results in only weak detection by magnetic resonance imaging (MRI) techniques. On the other hand, pathological ferritin is associated with disrupted iron homeostasis and structural changes in the mineral core, and should increase the hypointensive artefacts in MRI. On the basis of recent findings in respect to the pathological ferritin structure, we prepared the magnetoferritin particles as a possible pathological ferritin model system. The particles were characterised with dynamic light scattering, as well as with superconducting quantum interference device measurements. With the help of low-field (0.2 T) and high-field (4.7 T) MRI standard T-2-weighted protocols we found that it is possible to clearly distinguish between native ferritin as a physiological model system, and magnetoferritin as a pathological model system. Surprisingly, the T-2-weighted short TI inversion recovery protocol at low-field system showed the optimum contrast differentiation. Such findings are highly promising for exploiting the use of iron accumulation as a noninvasive diagnostics tool of pathological processes, where the magnetoferritin particles could be utilised as MRI iron quantification calibration samples.
机译：各种病理过程，包括神经退行性疾病与铁的积累相关联，而据信铁累积的前体铁蛋白。生理铁蛋白是由于低弛豫，这导致仅通过磁共振成像（MRI）技术弱检测。在另一方面，病理铁蛋白具有破坏的铁稳态，并在矿物核心结构变化相关联，并且应该增加在MRI的hypointensive假象。关于在病理铁结构最近的调查结果的基础上，我们准备好的magnetoferritin颗粒作为一个可能的病理铁蛋白模型系统。该颗粒进行了表征动态光散射，以及与超导量子干涉器件的测量。用低场（0.2 T）和高场（4.7 T），我们发现，有可能作为生理模型系统天然铁蛋白之间清楚地区分MRI标准T-2-加权协议和magnetoferritin的帮助下作为病理模型系统。出人意料的是，在低场系统中的T-2加权短TI反转恢复协议表明最佳对比度分化。这些发现是高度希望用于利用使用铁积累的病理过程的非侵入性诊断工具，其中，所述颗粒magnetoferritin可以用作MRI铁定量校准样品。

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