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首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Preventive potential of dietary inclusion of Brachystegia eurycoma (Harms) seeds on N-methyl-N-nitrosourea-induced colon carcinogenesis in Wistar rats
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Preventive potential of dietary inclusion of Brachystegia eurycoma (Harms) seeds on N-methyl-N-nitrosourea-induced colon carcinogenesis in Wistar rats

机译：在Wistar大鼠中对N-甲基-N-亚硝基脲脲脲植物诱导的rachystegia eurycoma（危害）种子的预防性潜力

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Ethnopharmacological relevance: Brachystegia eurycoma seed is used as dietary condiment and as part of recipes for treating colorectal disorders, while laboratory studies have established that it contains crude fiber and polyphenols which are important in cancer prevention. Aim of the study: To establish the efficacy of a Nigerian diet in colon cancer prevention, a study was conducted to evaluate dietary inclusion of Brachystegia eurycoma seed in experimental colon carcinogenesis. Methods: Rats undergoing intra-rectal instillations of N-Methyl-N-nitrosourea (MNU) were fed B. eurycoma included diets at 0%, 2.5%, 5% and 10% for a period often (10) weeks following which they were sacrificed; blood and tissues were monitored for biochemical, histological and immunohistochemical parameters. Results: Brachystegia eurycoma significantly (P < 0.05) prevented MNU-induced elevation of malondialdehyde and carcinoembryonic antigen (CEA) as well as reduced activities of catalase and superoxide dismutase. The colon showed deep mucosal ulceration with moderate inter-glandular inflammation in the MNU control group, but only mild or no inflammation was observed in the colon of the MNU groups fed experimental diets. Similarly, colon immunohistochemistry assay showed that the dietary inclusion significantly prevented MNU-induced damage to mismatch repair gene (MutL homolog1). Positive relationship existed between fiber content of B. eurycoma seeds and MutL homolog1 protein expression while that between polyphenol/flavonoids contents of diets and CEA was negative.
机译：Ethnopharmacological相关性：Brachystegia东革种子被用作膳食和调味品作为用于治疗结肠疾病配方的一部分，而实验室研究已经确定它含有粗纤维和多酚其在预防癌症重要。目的研究：建立预防结肠癌尼日利亚饮食的功效，研究，以评估在实验结肠癌的发生日粮中Brachystegia东革种子。方法：将大鼠经历N-甲基-N-亚硝基脲的直肠内滴注（MNU）为0％，2.5％，5％和10％饲喂B.东革包括饮食一段经常以下（10），周将它们牺牲;血液和组织用于生物化学，组织学和免疫组织化学参数进行监测。结果：过氧化氢酶和超氧化物歧化酶的Brachystegia东革显著（P <0.05）抑制MNU诱导的丙二醛和癌胚抗原（CEA）的仰角以及活动减少。结肠表现出深粘膜溃疡与MNU对照组中等间腺炎症，但在MNU组的结肠中观察到只有轻微或无炎症饲喂实验饮食。同样地，结肠免疫组化试验表明，所述饮食包含显著防止MNU诱导的损害到错配修复基因（MutL homolog1）。 B.东革种子纤维含量和MutL homolog1蛋白表达之间存在正相关，而饮食和CEA的多酚之间/黄酮含量为阴性。

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