...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs >Effects of a hydroethanolic extract of Boophone disticha bulb on anxiety-related behaviour in naive BALB/c mice
【24h】

Effects of a hydroethanolic extract of Boophone disticha bulb on anxiety-related behaviour in naive BALB/c mice

机译：胶酮脱酚醇提取物对幼稚BALB / C小鼠焦虑相关行为的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Ethnopharmacological relevance Boophone disticha is one of the most important medicinal bulbs of Southern Africa. Previous in vitro studies have shown that it's crude ethanolic extracts and some alkaloidal phytoconstituents possesses high affinity for the serotonin transporter protein (SERT) and serotonin receptor 1a (5HT 1a ) which are both implicated in the pathogenesis and treatment of anxiety disorders. However, there are no in vivo studies that validates the anxiolytic actions of the plant. Aim of the study This study was therefore set to determine the anxiolytic-like activity of an orally administered hydroethanolic extract of B. disticha bulbs in naive mice using the behavioural tests of anxiety. Materials and methods Na?ve adult male BALB/c mice were randomly placed into five treatment groups (n=6–10): vehicle control (10ml/kg 0.9% NaCl), positive control (1mg/kg diazepam) and the hydroethanolic extract of B. disticha (10, 25 and 40mg/kg p.o.). Souk test, elevared plus maze and open field tests were used to evaluate the anxiolytic-like activity of the B. disticha extract. Results Diazepam-treated mice exhibited higher number of sector visits and line crossings in the ST, rearings in the OF and head dips in the EPM than the control (p B. disticha extract treated groups expressed higher sector visits at 10mg/kg, and, unprotected head dips at 25mg/kg in the ST, as well as, open arm time entries at 10mg/kg dose, and unprotected head dips at all doses in the EPM than the control group (p B. disticha dose group exhibited highest anxiolytic-like activity in both the ST and OF, while the 10mg/kg was most active in the EPM. Conclusion The extract of B. disticha exerted good anxiolytic-like activity in both the ST and OF at medium dose (25mg/kg), while the low dose (10mg/kg) showed prominent anxiolytic-like activity in the EPM. Graphical abstract Display Omitted
机译：摘要民族科医药相关拓扑Disticha是南部非洲最重要的药用灯泡之一。之前的体外研究表明，它是粗乙醇提取物，一些生物植物植物组合物对血清素转运蛋白（Sert）和血清素受体1a（5ht 1a）具有高亲和力，这两者都涉及焦虑症的发病机制和治疗。然而，没有体内研究，验证植物的抗焦虑作用。因此，该研究的目的本研究确定了使用焦虑的行为试验确定幼稚小鼠中口服施用的硫酸甲酰胺提取物的抗焦虑症状活性。将材料和方法Na've成年雄性BALB / C小鼠随机置于五个处理基团（n = 6-10）：载体对照（10ml / kg 0.9％NaCl），阳性对照（1mg / kg diazemaam）和氢乙醇提取物B. disticha（10,25和40mg / kg po）。 SOUK测试，仅限加上迷宫和开放场测试来评估B. Disticha提取物的抗焦力样活性。结果Diazepam处理的小鼠在ST中展出了更高数量的扇形访问和线路交叉，在EPM中的饲养和头部浸在EPM中比对照（P. Disticha提取物治疗组在10mg / kg下表达更高的扇区访问，在ST中的25mg / kg处的未受保护的头部垂直，以及10mg / kg剂量的开口臂时间条目，并且在EPM中的所有剂量的未受保护的头部垂直于对照组（P. Distroicha剂量组表现出最高的抗焦虑 - 虽然ST和ST的活性相似，而10mg / kg在EPM中最活跃。结论B. districha的提取物在ST和中剂量（25mg / kg）中施加良好的抗焦虑症状活性低剂量（10mg / kg）在EPM中显示出突出的抗焦力样活性。省略了图形抽象显示

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号