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首页> 外文期刊>Journal of the Neurological Sciences: Official Bulletin of the World Federation of Neurology >Riluzole-induced interstitial lung disease is a rare and potentially life-threatening adverse event successfully treated with high-dose steroid therapy: Case reports and review of the literature
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Riluzole-induced interstitial lung disease is a rare and potentially life-threatening adverse event successfully treated with high-dose steroid therapy: Case reports and review of the literature

机译：Riluzole诱导的间质肺病是一种难得和潜在的危及生命的不良事件，用高剂量类固醇治疗成功治疗：案例报告和文献审查

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摘要

Riluzole (RZ)-induced interstitial lung disease (RZ-ILD) is a rare and potentially life-threatening adverse event in amyotrophic lateral sclerosis (ALS) patients, which is rarely reported. Therefore, the optimal treatment for RZ-ILD is unclear. We describe herein three Japanese cases of ALS complicated with RZ-ILD, of which two were successfully treated with high-dose steroid therapy. In our all ALS cases with RZ-ILD, the duration of RZ exposure until RZ-ILD onset was within 2 months. All three cases showed respiratory symptoms, dorsal predominant ground-glass opacities by imaging analysis, and abnormal laboratory findings associated with interstitial lung diseases, such as Krebs von den Lungen-6 and surfactant protein-D. Intravenous high-dose steroid therapy together with the discontinuation of RZ in two cases with respiratory symptoms markedly ameliorated their symptoms and abnormal findings of RZ-ILD. One case showed mild respiratory symptoms compared with the others and recovered after the withdrawal of RZ only. According to previous case reports and our cases, RZ-ILD may develop 2 months after initiating RZ and exacerbate respiratory symptoms rapidly in ALS patients with severe respiratory muscle involvement or complicating aspiration pneumonia. Transient high-dose steroid therapy in addition to discontinuation of RZ might be a good therapeutic option for RZ-ILD.
机译：Riluzole（RZ）诱导的间质肺病（RZ-ILD）是肌营养的侧面硬化症（ALS）患者的罕见和潜在的危及生命的不良事件，很少报道。因此，RZ-ILD的最佳处理尚不清楚。我们在此描述了三种与Rz-ILD复杂的ALS的日本病例，其中两种均用高剂量类固醇疗法成功治疗。在我们的所有ALS案例中，RZ-ILD，RZ暴露的持续时间直到RZ-ILD发作在2个月内。所有三种病例都显示出呼吸系统症状，通过成像分析，与间质肺疾病相关的异常实验室发现，如Krebs Von Den Lungen-6和表面活性剂蛋白-D。静脉内高剂量类固醇治疗与呼吸系统症状中的两种情况下停止RZ显着改善了其症状和RZ-ILD的异常发现。一个病例显示出轻度呼吸系统症状与其他呼吸症状，并在RZ撤离后恢复。根据之前的报告和我们的病例，RZ-ILD在迅速在患有严重呼吸肌的参与或复杂性肺炎的ALS患者中迅速发起和加剧呼吸道症状后2个月。瞬态高剂量类固醇疗法除了停止RZ之外，RZ-ILD可能是一个很好的治疗选择。

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