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首页> 外文期刊>Current pharmaceutical design >Non-Analgesic Effects of Opioids: Cardiovascular Effects of Opioids and their Receptor Systems.
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Non-Analgesic Effects of Opioids: Cardiovascular Effects of Opioids and their Receptor Systems.

机译：阿片类药物的非镇痛作用：阿片类药物及其受体系统的心血管作用。

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摘要

Opioid peptides and their G protein-coupled receptors (GPCRs) are important regulators within the cardiovascular system, implicated in modulation of electrophysiological function, heart rate, myocardial inotropy, vascular function, and cellular stress resistance. The opioid system is also involved in cardiovascular development, adaptation to injury and effects of advanced age. The significant roles of opioids are emphasized by the observation that the heart produces prodynorphin and proenkephalin, which are enzymatically processed from small to large active polypeptides. Indeed, depending on species, cardiac preproenkephalin mRNA levels are comparable to or higher than those found in the central nervous system. This review highlights and discusses current knowledge and recent findings regarding physiological and pathophysiological modulation of the heart and vessels by the opioid receptor system.
机译：阿片肽及其G蛋白偶联受体（GPCR）是心血管系统中的重要调节剂，与电生理功能，心率，心肌肌力，血管功能和细胞应激抗性的调节有关。阿片类药物系统还参与心血管的发展，对损伤的适应和高龄的影响。阿片类药物的重要作用是通过观察到心脏会产生前强啡肽和前脑啡肽来强调的，前强啡肽和前脑啡肽是通过酶法从小到大的活性多肽加工而成的。实际上，根据物种的不同，心脏前脑啡肽原mRNA的水平与中枢神经系统中的水平相当或更高。这篇综述着重讨论了阿片受体系统对心脏和血管的生理和病理生理调节的最新知识和最新发现。

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