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Low-dose weekly paclitaxel therapy proved useful for a case of recurrent gastric cancer with clinically latent hepatic cirrhosis

机译:低剂量每周紫杉醇疗法证明是有用的患有临床潜在肝肝硬化的复发性胃癌

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摘要

The patient was a 68-year-old-man who suffered from recurrent peritoneal gastric cancer. He was initially treated with TS-1 as an outpatient. However, his serum CEA level elevated in March 2004, and he complained of epigastric pain in June. A chest and abdominal CT revealed lung and local recurrence. He began weekly paclitaxel as second-line chemotherapy in September. Paclitaxel was infused once a week for two weeks as one cycle, at a dose of 60 mg because of the clinically latent hepatic cirrhosis. One month after the first infusion therapy, epigastric pain was greatly reduced. A CT scan showed the lung metastasis had disappeared and the size of the tumor around the anastomosis was reduced to 50% after 2 months. The toxic events were appetite loss (grade 2) and alopecia (grade 2).
机译:患者是一名68岁的人,患有经常性腹膜胃癌。 他最初用TS-1作为门诊治疗。 然而,他的血清CEA水平于2004年3月提升,他于6月份抱怨昙花一现。 胸部和腹部CT揭示了肺和局部复发。 他于9月开始每周服用紫杉醇作为二线化疗。 Paclitaxel每周注入一次两周作为一个循环,以60毫克的剂量,因为临床潜在的肝硬化。 在第一次输液治疗后一个月,大大减少了昙花一现。 CT扫描显示肺转移消失,2个月后吻合肿瘤周围的肿瘤的大小降至50%。 毒性事件是食欲损失(2级)和Alopecia(2级)。

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