Evaluation of public health interventions for Anthrax: a report to the secretary's council on Public Health Preparedness.

Wein LM; Craft DL

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Evaluation of public health interventions for Anthrax: a report to the secretary's council on Public Health Preparedness.

机译：炭疽病公共卫生干预措施的评估：向秘书委员会提供的关于公共卫生防范的报告。

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To aid in understanding how best to respond to a bioterror anthrax attack, we analyze a system of differential equations that includes a disease progression model, a set of spatially distributed queues for distributing antibiotics, and vaccination (pre-event and/or post-event). We derive approximate expressions for the number of casualties as a function of key parameters and management levers, including the time at which the attack is detected, the number of days to distribute antibiotics, the adherence to prophylactic antibiotics, and the fraction of the population that is preimmunized. We compare a variety of public health intervention policies in the event of a hypothetical anthrax attack in a large metropolitan area. Modeling assumptions were decided by the Anthrax Modeling Working Group of the Secretary's Council on Public Health Preparedness. Our results highlight the primary importance of rapid antibiotic distribution and lead us to argue for ensuring post-attack surge capacity to rapidly produce enough anthrax vaccine for an additional 100 million people.

机译：为了帮助理解如何最好地应对生物恐怖炭疽热发作，我们分析了一个微分方程系统，其中包括疾病进展模型，一组用于分配抗生素的空间分布队列以及接种疫苗（事前和/或事后）。我们得出的伤亡人数的近似表达式是关键参数和管理手段的函数，包括检测到袭击的时间，分发抗生素的天数，对预防性抗生素的依从性以及所占人群的比例已预先免疫。我们比较了在大都市地区发生假设性炭疽发作时的各种公共卫生干预政策。建模假设由秘书委员会公共卫生防范炭疽模型工作组决定。我们的结果凸显了快速分配抗生素的首要重要性，并促使我们为确保攻击后的激增能力迅速为另外1亿人生产足够的炭疽疫苗而争论不休。

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《Biosecurity and bioterrorism: Biodefense Strategy, Practice, and Science》 |2005年第4期|共9页
作者
Wein LM; Craft DL;
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正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;生物科学;
关键词
Anthrax; Bioterrorism; Disease Outbreaks; Public Health Practice; 炭疽; 疾病暴发流行; 公共卫生工作;

机译：Anthrax;Bioterrorism;Disease Outbreaks;Public Health Practice;炭疽;疾病暴发流行;公共卫生工作;

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1. Evaluation of public health interventions for Anthrax: a report to the secretary's council on Public Health Preparedness. [J] . Wein LM, Craft DL Biosecurity and bioterrorism: Biodefense Strategy, Practice, and Science . 2005,第4期

机译：炭疽病公共卫生干预措施的评估：向秘书委员会提供的关于公共卫生防范的报告。
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6. Evaluating Public Health Interventions: 2. Stepping Up to Routine Public Health Evaluation With the Stepped Wedge Design [O] . Donna Spiegelman 2016

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机译：公共卫生报告，美国公共卫生服务期刊，第109卷，第2期，1994年3月至4月。（包括）特节：秘书获得健康促进和疾病预防创新奖的获奖者

Evaluation of public health interventions for Anthrax: a report to the secretary's council on Public Health Preparedness.

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