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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >The Relationship Between 24-Hour Symptoms and COPD Exacerbations and Healthcare Resource Use: Results from an Observational Study (ASSESS)
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The Relationship Between 24-Hour Symptoms and COPD Exacerbations and Healthcare Resource Use: Results from an Observational Study (ASSESS)

机译：24小时症状与COPD恶化和医疗资源使用之间的关系：一项观察性研究（ASSESS）的结果

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This observational study assessed the relationship between nighttime, early-morning and daytime chronic obstructive pulmonary disease (COPD) symptoms and exacerbations and healthcare resource use. COPD symptoms were assessed at baseline in patients with stable COPD using a standardised questionnaire during routine clinical visits. Information was recorded on exacerbations and healthcare resource use during the year before baseline and during a 6-month follow-up period. The main objective of the analysis was to determine the predictive nature of current symptoms for future exacerbations and healthcare resource use. 727 patients were eligible (65.8% male, mean age: 67.2 years, % predicted forced expiratory volume in 1 second: 52.8%); 698 patients (96.0%) provided information after 6 months. Symptoms in any part of the day were associated with a prior history of exacerbations (all p < 0.05) and nighttime and early-morning symptoms were associated with the frequency of primary care visits in the year before baseline (both p < 0.01). During follow-up, patients with baseline symptoms during any part of the 24-hour day had more exacerbations than patients with no symptoms in each period (all p < 0.05); there was also an association between 24-hour symptoms and the frequency of primary care visits (all p <= 0.01). Although there was a significant association between early-morning and daytime symptoms and exacerbations during follow-up (both p < 0.01), significance was not maintained when adjusted for potential confounders. Prior exacerbations were most strongly associated with future risk of exacerbation. The results suggest 24-hour COPD symptoms do not independently predict future exacerbation risk.
机译：这项观察性研究评估了夜间，早晨和白天的慢性阻塞性肺疾病（COPD）症状与病情加重之间的关系以及医疗资源的使用。在常规临床就诊期间，使用标准问卷对稳定型COPD患者的基线COPD症状进行评估。在基线之前的一年和6个月的随访期内记录了有关病情加重和医疗资源使用的信息。分析的主要目的是确定当前症状的预测性质，以供日后加重和医疗资源使用。 727例患者合格（男性65.8％，平均年龄：67.2岁，1秒内预计的强制呼气量百分比：52.8％）; 6个月后，有698例患者（96.0％）提供了信息。一天中任何一天的症状都与病情加重的既往史相关（所有p <0.05），夜间和早起症状与基线前一年的基层就诊次数相关（均p <0.01）。在随访期间，在每个时段的24小时内具有基线症状的患者加重的病情多于每个时期无症状的患者（所有p <0.05）; 24小时症状与初级保健就诊频率之间也存在关联（所有p <= 0.01）。尽管早期随访与白天症状和随访期间病情加重之间存在显着相关性（均p <0.01），但对潜在的混杂因素进行调整后，其显着性并未得到维持。先前加重与将来加重的风险最密切相关。结果表明24小时COPD症状不能独立预测未来加重的风险。

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