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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Cardiac autonomic function and cardiovascular response to exercise in patients with chronic obstructive pulmonary disease
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Cardiac autonomic function and cardiovascular response to exercise in patients with chronic obstructive pulmonary disease

机译：慢性阻塞性肺疾病患者的心脏自主神经功能和运动对心血管的反应

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Background: Chronic obstructive pulmonary disease (COPD) is associated with impaired exercise tolerance, but it has not been established to what extent cardiac autonomic function impacts on exercise capacity. Objective: To evaluate whether there is an association between airflow limitation and cardiac autonomic function and whether cardiac autonomic function plays a role in exercise intolerance and daily physical activity (PA) in patients with COPD. Methods: Univariate and multivariate analyses were performed to evaluate the association between both 6-minute walking test (6MWT) and PA (steps per day) and pulmonary function, cardiac autonomic function (HR at rest, HRR and heart rate variability, HRV) in patients with COPD. Results: In 154 COPD patients (87 females, mean [SD]: age 62.5 [10.7] years, FEV 1 %predicted (43.0 [19.2]%), mean HR at rest was elevated (86.4 [16.4] beats/min) and HRV was reduced (33.69 [28.96] ms) compared to published control data. There was a significant correlation between FEV 1 and HR at rest (r = -0.32, p 0.001), between HR at rest and 6MWD (r = -0.26, p = 0.001) and between HR at rest and PA (r = -0.29, p = 0.010). No correlation was found between HRV and 6MWD (r = 0.089, p = 0.262) and PA (r = 0.075, p = 0.322). In multivariate analysis both HR and FEV 1 were independent predictors of exercise capacity in patients with COPD. Conclusions: In patients with COPD the degree of airflow limitation is associated with HR at rest. The degree of airflow limitation and cardiac autonomic function, as quantified by HR at rest, are independently associated with exercise capacity in patients with COPD.
机译：背景：慢性阻塞性肺疾病（COPD）与运动耐力受损有关，但尚不能确定心脏自主功能对运动能力的影响程度。目的：评估气流受限与心脏自主神经功能之间是否存在关联，以及心脏自主神经功能是否在COPD患者的运动耐量和日常身体活动（PA）中发挥作用。方法：进行单因素和多因素分析，以评估6分钟步行测试（6MWT）和PA（每天步数）与肺功能，心脏自主神经功能（静息HR，HRR和心率变异性，HRV）之间的关系。 COPD患者。结果：在154例COPD患者中（87名女性，平均[SD]：年龄62.5 [10.7]岁，预测的FEV为1％（43.0 [19.2]％），平均静息心率升高（86.4 [16.4]次/分钟），并且与已发表的对照数据相比，HRV降低了（33.69 [28.96] ms）。FEV 1与静止时的心率之间存在显着相关性（r = -0.32，p <0.001），静止时的心率与6MWD之间存在显着相关性（r = -0.26） ，p = 0.001）以及静息时的心率和PA之间（r = -0.29，p = 0.010）.HRV和6MWD（r = 0.089，p = 0.262）和PA（r = 0.075，p = 0.322）之间没有相关性）。在多变量分析中，HR和FEV 1都是COPD患者运动能力的独立预测指标结论：COPD患者的气流受限程度与静息HR相关，气流受限程度和心脏自主神经功能COPD患者静息时的HR定量与运动能力无关。

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