...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Effect of bronchial colonisation on airway and systemic inflammation in stable COPD
【24h】

Effect of bronchial colonisation on airway and systemic inflammation in stable COPD

机译：稳定COPD中支气管定植对气道和全身炎症的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The recovery of potentially pathogenic microorganisms (PPMs) from bronchial secretions is associated with a local inflammatory response in COPD patients. The objective of this study was to determine the relationships between bronchial colonisation and both bronchial and systemic inflammation in stable COPD. In COPD patients recruited on first admission for an exacerbation, bacterial sputum cultures, interleukin (IL)-1β, IL-6 and IL-8 levels, and blood C-reactive protein (CRP) were measured in stable condition. Bronchial colonisation was found in 39 of the 133 (29%) patients and was significantly related to higher sputum IL-1β (median [percentile 25-75]; 462 [121-993] vs. 154 [41-477] pg/ml, p = 0.002), IL-6 (147 [71-424] vs. 109 [50-197] pg/ml, p = 0.047) and IL-8 values (15 [9-19] vs. 8 [3-15] (×10 3) pg/ml, p = 0.002). Patients with positive cultures also showed significantly elevated levels of serum CRP (6.5 [2.5-8.5] vs. 3.5 [1.7-5.4] mg/l, p = 0.016). Bronchial colonisation by Haemophilus influenzae was associated with higher levels of IL-1β and IL-8 and clinically significant worse scores on the activity and impact domains of the St. George's Respiratory Questionnaire. In conclusion, bronchial colonisation is associated with bronchial inflammation and high blood CRP levels in stable COPD patients, being Haemophilus influenzae related to a more severe inflammatory response and impairment in health-related quality of life.
机译：从支气管分泌物中恢复潜在致病微生物（PPM）与COPD患者的局部炎症反应有关。这项研究的目的是确定稳定COPD中支气管定植与支气管和全身炎症之间的关系。在首次入院以加重病情入院的COPD患者中，在稳定的条件下测量了细菌痰培养物，白介素（IL）-1β，IL-6和IL-8水平以及血液C反应蛋白（CRP）。在133例患者中有39例（29％）发现支气管定植，并且与痰液中IL-1β升高显着相关（中位[百分位数25-75]; 462 [121-993]与154 [41-477] pg / ml ，p = 0.002），IL-6（147 [71-424]与109 [50-197] pg / ml，p = 0.047）和IL-8值（15 [9-19]与8 [3- 15]（×10 3）pg / ml，p = 0.002）。培养阳性的患者血清CRP水平也显着升高（6.5 [2.5-8.5] vs. 3.5 [1.7-5.4] mg / l，p = 0.016）。流感嗜血杆菌支气管定植与较高水平的IL-1β和IL-8相关，并且在圣乔治呼吸调查问卷的活动和影响范围内，临床上评分较差。总之，在稳定的COPD患者中，支气管定植与支气管炎症和高血CRP水平有关，流感嗜血杆菌与更严重的炎症反应和健康相关的生活质量受损有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号