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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >The association between periodontal disease and chronic obstructive pulmonary disease: A case control study
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The association between periodontal disease and chronic obstructive pulmonary disease: A case control study

机译：牙周疾病与慢性阻​​塞性肺疾病之间的关联：病例对照研究

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Introduction: Although there are studies evaluating the effects of periodontal health on chronic obstructive pulmonary disease (COPD), the effects of COPD-a systemic disease, on periodontal tissue is unknown. The aim of this study is to evaluate the effects of COPD on periodontal tissues by comparing COPD patients and controls. Methods: Fifty-two COPD patients and 38 non-COPD controls were included in this case-control study. Number of teeth, plaque index (PI), gingival index (GI), bleeding on probing, clinical attachment level and probing depth were included in the periodontal examination. In addition to clinical evaluations, gingival crevicular fluid (GCF) levels of high-sensitive C-reactive protein (hs-CRP), interleukin-1 beta (IL-lb) and prostaglandin-E2 (PGE2), and serum hs-CRP levels were measured in COPD patients and the controls. Results: The number of teeth was significantly lower while PI and GI were significantly higher in COPD patients when compared to the controls. As well as serum hs-CRP levels, the GCF levels of hs-CRP, IL-1b and PGE2 were significantly higher in COPD patients than the controls. Conclusion: Our results demonstrated that COPD may be associated with periodontal disease as manifested by lower number of teeth and higher levels of inflammatory mediators especially CRP in GCF. This finding may be a reflection of systemic effects of COPD on periodontal tissues. Poor oral health behavior of COPD patients have to be considered in larger size group studies in the future.
机译：简介：尽管已有研究评估牙周健康对慢性阻塞性肺疾病（COPD）的影响，但COPD-a系统性疾病对牙周组织的影响尚不清楚。这项研究的目的是通过比较COPD患者和对照组来评估COPD对牙周组织的影响。方法：本病例对照研究包括52例COPD患者和38例非COPD对照。牙周检查包括牙齿数目，牙菌斑指数（PI），牙龈指数（GI），探查出血，临床依从水平和探查深度。除了临床评估外，牙龈沟液（GCF）的高敏C反应蛋白（hs-CRP），白介素1 beta（IL-1lb）和前列腺素E2（PGE2）的水平以及血清hs-CRP的水平在COPD患者和对照组中进行了测量。结果：与对照组相比，COPD患者的牙齿数量明显减少，而PI和GI则明显增加。除了血清hs-CRP水平外，COPD患者中hs-CRP，IL-1b和PGE2的GCF水平也显着高于对照组。结论：我们的结果表明，COPD可能与牙周疾病有关，表现为牙齿数量减少和炎症介质（尤其是GCF中的CRP）水平升高。这一发现可能反映了COPD对牙周组织的全身作用。将来在较大规模的小组研究中必须考虑COPD患者的不良口腔健康行为。

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