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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Validation of the i-BODE index as a predictor of hospitalization and mortality in patients with COPD participating in pulmonary rehabilitation
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Validation of the i-BODE index as a predictor of hospitalization and mortality in patients with COPD participating in pulmonary rehabilitation

机译：i-BODE指数可作为参与肺康复的COPD患者住院和死亡率的预测指标

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The aim of this study was to examine the value of the i-BODE index to predict hospital admission and to confirm its usefulness to predict mortality in a Danish population. The incremental shuttle walking test (ISWT) is widely used in the UK and Europe and previous work has examined the replacement of the 6MWT with the ISWT within the BODE index for predicting the prognosis of COPD (i-BODE). The 674 patients included in the analysis participated in a 7-week pulmonary rehabilitation program from 2002 to 2011. The National Health Services Central Register ascertained vital status and provided information on all hospital admissions. The mean follow-up period was 66 months (range 11-118 months). Cox proportional hazards model was used to identify factors that significantly predicted mortality and time to first hospital admission. The i-BODE index as well as body mass index, MRC dyspnea grade, and exercise capacity (ISWT) were significantly associated with all-cause mortality. The adjusted hazard ratio for death per one point increase in the i-BODE score was 1.28 (95% confidence interval 1.20 to 1.37). The i-BODE index was also a significant predictor of hospitalization, both for all causes and COPD exacerbation. Patients in the highest i-BODE quartile had a median time to first hospitalization of 17 months compared to 51 months for patients in the lowest quartile. The i-BODE index is a significant predictor of hospital admission and thus health care utilization, and also mortality.
机译：这项研究的目的是检验i-BODE指数的价值，以预测住院人数并确认其在预测丹麦人群死亡率方面的作用。增量穿梭步行试验（ISWT）在英国和欧洲广泛使用，以前的工作已经在BODE指数内检查了用ISWT替代6MWT来预测COPD（i-BODE）的预后。分析中包括的674例患者从2002年到2011年参加了为期7周的肺康复计划。国家卫生服务中央登记簿确定了生命状态，并提供了所有入院信息。平均随访期为66个月（范围11-118个月）。使用Cox比例风险模型来识别可显着预测死亡率和首次住院时间的因素。 i-BODE指数以及体重指数，MRC呼吸困难等级和运动能力（ISWT）与全因死亡率密切相关。 i-BODE分数每升高1个百分点，调整后的死亡危险比为1.28（95％置信区间1.20至1.37）。 i-BODE指数也是所有原因和COPD恶化的住院率的重要预测指标。 i-BODE四分位数最高的患者首次住院的平均时间为17个月，而四分位数最低的患者为51个月。 i-BODE指数是医院入院率，医疗保健利用率以及死亡率的重要预测指标。

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