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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Minimum Clinically Important Difference in Diffusing Capacity of the Lungs for Carbon Monoxide Among Patients with Severe and Very Severe Chronic Obstructive Pulmonary Disease
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Minimum Clinically Important Difference in Diffusing Capacity of the Lungs for Carbon Monoxide Among Patients with Severe and Very Severe Chronic Obstructive Pulmonary Disease

机译：重度和重度慢性阻塞性肺疾病患者肺对一氧化碳扩散能力的最小临床重要差异

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Background: The minimum clinically important difference (MCID) for diffusing capacity of the lungs for carbon monoxide (DLCO) has not yet been solidly established. Methods: We used the dataset of surgical cohort of National Emphysema Treatment Trial. Briefly, severe and very severe chronic obstructive pulmonary disease (COPD) patients who were candidate for volume reduction surgery and who could provide sufficient data at 12-month follow-up were included. We used two anchor methods using 6-minute walk distance (6MWD. MCID = 40 m) and forced expiratory volume in 1 sec (FEV1. MCID = 100 ml) as anchors, and two distribution methods. We proposed MCID with a median of estimated values. We estimated MCID for DLCO in raw value and % change from the baseline independently. Results: The surgical cohort included 356 patients, whose average age was 66.6 +/- 5.5 years, and the average % predicted FEV 1 was 27.8 +/- 7.3%. The estimated MCID for DLCO in raw value and % change from the baseline were as follows: anchor method (average, 6MWD) 1.2 ml/min/mmHg, 17%; anchor method (average, FEV1) 0.7 ml/min/mmHg, 11%; anchor method (receiver operating characteristic, 6MWD) 1.1 ml/min/mmHg, 10%; anchor method (receiver operating characteristic, FEV1) 1.2 ml/min/mmHg, 3%; distribution method (0.3 units of standard deviation), 0.9 ml/min/mmHg, 11%; distribution method (standard error of measurement), 1.1 ml/min/mmHg. The median of these values was 1.1 ml/min/mmHg and 11%. Conclusion: We estimated the group-level MCID for DLCO for patients with severe and very severe COPD patients as 1.1 ml/min/mmHg and 11% of baseline DLCO.
机译：背景：尚未确定用于肺部扩散一氧化碳（DLCO）的最小临床重要差异（MCID）。方法：我们使用了国家肺气肿治疗试验手术队列的数据集。简而言之，纳入了重度和非常重度的慢性阻塞性肺疾病（COPD）患者，这些患者可以进行减容手术，并且在12个月的随访中可以提供足够的数据。我们使用了两种锚定方法，分别以6分钟的步行距离（6MWD。MCID = 40 m）和1秒内的呼气量（FEV1。MCID = 100 ml）作为锚定，以及两种分配方法。我们提出了MCID和估计值的中位数。我们估计了DLCO的MCID的原始值和相对于基线的变化百分比。结果：该手术队列包括356例患者，平均年龄为66.6 +/- 5.5岁，预计FEV 1的平均百分比为27.8 +/- 7.3％。估计的DLCO的MCID的原始值和相对于基线的百分比变化如下：锚定方法（平均6MWD）1.2 ml / min / mmHg，17％;锚定法（平均值，FEV1）0.7 ml / min / mmHg，11％;锚定法（接收器工作特性，6MWD）1.1 ml / min / mmHg，10％;锚定方法（接收机工作特性，FEV1）1.2 ml / min / mmHg，3％;分配方法（0.3单位标准偏差），0.9 ml / min / mmHg，11％;分配方法（标准测量误差），1.1 ml / min / mmHg。这些值的中位数为1.1 ml / min / mmHg和11％。结论：我们估计重度和非常重度COPD患者的DLCO的组级MCID为1.1 ml / min / mmHg，占基线DLCO的11％。

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