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首页> 外文期刊>COPD: Journal of Chronic Obstructive Pulmonary Disease >Overweight and Obesity May Lead to Under-diagnosis of Airflow Limitation: Findings from the Copenhagen City Heart Study
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Overweight and Obesity May Lead to Under-diagnosis of Airflow Limitation: Findings from the Copenhagen City Heart Study

机译：超重和肥胖可能导致对气流受限的诊断不足：哥本哈根市心脏研究的发现

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摘要

Background: The prevalence of obesity has increased during the last decades and varies from 10-20% in most European countries to approximately 32% in the United States. However, data on how obesity affects the presence of airflow limitation (AFL) defined as a reduced ratio between forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) are scarce. Methods: Data was derived from the third examination of the Copenhagen City Heart Study from 1991 until 1994 (n = 10,135). We examine the impact of different adiposity markers (weight, body mass index (BMI), waist circumference, waist-hip ratio, and abdominal height) on AFL. AFL was defined in four ways: FEV1/FVC ratio < 0.70, FEV1/FVC ratio < lower limit of normal (LLN), FEV1/FVC ratio < 0.70 including at least one respiratory symptom, and FEV1/FVC ratio < LLN and FEV1 % of predicted < LLN. Results: All adiposity markers were positively and significantly associated with FEV1/FVC independent of age, sex, height, smoking status, and cumulative tobacco consumption. Among all adiposity markers, BMI was the strongest predictor of FEV1/FVC. FEV1/FVC increased with 0.04 in men and 0.03 in women, as BMI increased with 10 units (kg . m(-2)). Consequently, diagnosis of AFL was significantly less likely in subjects with BMI = 25 kg . m(-2) with odds ratios 0.63 or less compared to subjects with BMI between 18.5-24.9 kg . m(-2) when AFL was defined as FEV1/FVC < 0.70. Conclusion: High BMI reduces the probability of AFL. Ultimately, this may result in under-diagnosis and under-treatment of COPD among individuals with overweight and obesity.
机译：背景：在过去的几十年中，肥胖症的患病率有所上升，从大多数欧洲国家的10％至20％到美国的32％不等。但是，关于肥胖如何影响气流受限（AFL）（定义为1秒内强制呼气量（FEV1）和强制肺活量（FVC）之间的比率降低）的数据很少。方法：数据来自1991年至1994年哥本哈根市心脏研究的第三次检查（n = 10,135）。我们检查了不同的肥胖标志物（体重，体重指数（BMI），腰围，腰臀比和腹部高度）对AFL的影响。 AFL有以下四种定义：FEV1 / FVC比<0.70，FEV1 / FVC比<正常下限（LLN），FEV1 / FVC比<0.70，包括至少一种呼吸道症状，FEV1 / FVC比

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