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首页> 外文期刊>Chronobiology international >Suprachiasmatic nuclei may regulate the rhythm of leptin hormone release in Syrian hamsters (Mesocricetus auratus)
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Suprachiasmatic nuclei may regulate the rhythm of leptin hormone release in Syrian hamsters (Mesocricetus auratus)

机译：视交叉上核可能调节叙利亚仓鼠（Mesocricetus auratus）瘦素激素释放的节奏

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摘要

The suprachiasmatic nuclei (SCN) generate the circadian rhythm of many hormones. The hormone leptin is a metabolic signal that informs the brain about fat and energy stores of the body. We investigated whether the rhythm of leptin hormone release in Syrian hamsters is directly controlled by the SCN. Three experiments were performed: in the first, hamsters were SCN-lesioned; in the second, hamsters were exposed to different feeding regimes; and in the third, hamsters were adrenalectomized and implanted with cortisol capsules to maintain constant glucocorticoid release. Blood samples were collected before and after the experiments at different clock times and examined for leptin levels by enzyme-linked immunosorbant assay (ELISA). Different feeding regimes and constant glucocorticoid release did not alter the rhythm of leptin release; whereas, SCN lesions abolished the rhythm. The results of the present study suggest the rhythm in leptin release in Syrian hamsters may be controlled by the SCN.
机译：视交叉上核（SCN）产生许多激素的昼夜节律。瘦素激素是一种代谢信号，可告知大脑体内的脂肪和能量储存。我们调查了SCN是否直接控制了叙利亚仓鼠瘦素激素释放的节奏。进行了三个实验：首先，仓鼠被SCN损伤;第二，仓鼠暴露于不同的喂养方式。第三步，将仓鼠肾上腺切除并植入皮质醇胶囊以维持糖皮质激素的持续释放。在实验之前和之后在不同的时钟时间收集血液样品，并通过酶联免疫吸附测定（ELISA）检查瘦素水平。不同的喂养方式和糖皮质激素的持续释放不会改变瘦素释放的节奏。而SCN病变取消了节律。本研究结果表明叙利亚仓鼠瘦素释放的节奏可能受SCN控制。

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