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Melatonin in the multi-oscillatory mammalian circadian world

机译:哺乳动物多节律性昼夜节律中的褪黑激素

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摘要

In mammals, the complex interaction of neural, hormonal, and behavioral outputs from the suprachiasmatic nucleus (SCN) drives circadian expression of events, either directly or through coordination of the timing of peripheral oscillators. Melatonin, one of the endocrine output signals of the clock, provides the organism with circadian information and can be considered as an endogenous synchronizer, able to stabilize and reinforce circadian rhythms and to maintain their mutual phase-relationship at the different levels of the circadian network. Moreover, exogenous melatonin, through an action on the circadian clock, affects all levels of the circadian network. The molecular mechanisms underlying this chronobiotic effect have also been investigated in rats. REV-ERB alpha seems to be the initial molecular target.
机译:在哺乳动物中,视交叉上神经(SCN)的神经,激素和行为输出的复杂相互作用直接或通过协调外围振荡器的时间来驱动事件的昼夜表达。褪黑激素是时钟的内分泌输出信号之一,可为生物体提供昼夜节律信息,可以被认为是一种内源性同步器,能够稳定和增强昼夜节律,并在昼夜节律网络的不同水平上维持它们相互的相位关系。 。此外,外源性褪黑激素通过对生物钟的作用影响生物钟网络的所有水平。还已经在大鼠中研究了这种计时生长期作用的分子机制。 REV-ERBα似乎是最初的分子靶标。

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