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首页> 外文期刊>Chronobiology international >PACAP - A multifacetted neuropeptide
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PACAP - A multifacetted neuropeptide

机译：PACAP-多方面的神经肽

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摘要

Pituitary adenylate cyclase activating polypeptide (PACAP) was originally isolated from ovine hypothalamus based on its ability to stimulate cAMP production in pituitary cell cultures. The peptide exists in two forms, both of which are derived from the same precursor. PACAP38 and the C-terminal truncated PACAP27 can interact with three subtypes of receptors activating adenylate cyclase and/or phospholipase C. Since its discovery, numerous studies have provided evidence that PACAP is a pleiotropic substance having a broad spectrum of biological functions; the peptide can act as a hormone, neurohormone, autocrine/paracrine substance, neurotransmitter, neuromodulator, neurotrophic factor, and immunomodulator. Two examples of the functional role of PACAP on the biological timing system are presented: 1) the transient expression of PACAP during the periovulatory period in ovarian cells, in which PACAP functions as an autocrine/paracrine inducer of progesterone secretion and subsequent luteinization; and 2) the role of PACAP as a neurotransmitter in the retinohypothalamic tract mediating photic regulation of the brain's biological clock.
机译：垂体腺苷酸环化酶激活多肽（PACAP）最初是根据其在垂体细胞培养物中刺激cAMP产生的能力从绵羊下丘脑中分离出来的。该肽以两种形式存在，两者均源自同一前体。 PACAP38和C端截短的PACAP27可以与激活腺苷酸环化酶和/或磷脂酶C的三种受体亚型相互作用。自发现以来，许多研究提供了证据，证明PACAP是一种具有多种生物学功能的多效性物质。该肽可用作激素，神经激素，自分泌/旁分泌物质，神经递质，神经调节剂，神经营养因子和免疫调节剂。展示了PACAP在生物计时系统上的功能作用的两个例子：1）PACAP在卵巢细胞的排卵周期中的瞬时表达，其中PACAP充当孕激素分泌和随后的黄体化的自分泌/旁分泌诱导剂; 2）PACAP作为神经递质在视网膜下丘脑束介导大脑生物钟的光调节中的作用。

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