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Two Surface Activation Strategies to Functionalize Cotton Fibers with Cys-LC-LL-37 Antibacterial Peptide

机译:用Cys-LC-LL-37抗菌肽功能化棉纤维的两种表面活化策略

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摘要

This investigation aimed to determine which of two surface activation methods, N,N’-carbonyldiimidazole (CDI) or 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO), allowed more effective bonding of Cys-LC-LL-37, an antimicrobial peptide (AMP), onto cotton fibers and which one presented greater antimicrobial activity. The antibacterial effect of the TEMPO- activated cotton functionalized with Cys-LC-LL-37 was more effective against Staphylococcus aureus, while the CDI-activated cotton covalently bonded to Cys-LC-LL-37 was more effective against Klebsiella pneumoniae. CDI-activated cotton retained a higher percentage of the AMP, making this bioactive strategy the choice for development of AMP antimicrobial textiles.
机译:这项研究旨在确定N,N'-羰基二咪唑(CDI)或2,2,6,6-四甲基哌啶-1-氧基(TEMPO)这两种表面活化方法中的哪一种可以更有效地结合Cys-LC-LL- 37,一种抗微生物肽(AMP),位于棉纤维上,其中一种具有更大的抗微生物活性。用Cys-LC-LL-37功能化的TEMPO活化棉的抗菌作用对金黄色葡萄球菌更有效,而与Cys-LC-LL-37共价结合的CDI活化棉对肺炎克雷伯菌更有效。 CDI活化棉保留了较高的AMP百分比,使这种生物活性策略成为开发AMP抗菌纺织品的选择。

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